Boc-Tra-Phe-4-ethoxycarbonylanilinomethyl ketone

Base Information

• Chemical Name: Boc-Tra-Phe-4-ethoxycarbonylanilinomethyl ketone
• CAS No.: 152438-45-4
• Molecular Formula: C₃₂H₄₃N₃O₆
• Molecular Weight: 565.71
• Mol file: 152438-45-4.mol

Synonyms:Boc-Tra-Phe-4-ethoxycarbonylanilinomethyl ketone

Chemical Property of Boc-Tra-Phe-4-ethoxycarbonylanilinomethyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Tra-Phe-4-ethoxycarbonylanilinomethyl ketone

There total 7 articles about Boc-Tra-Phe-4-ethoxycarbonylanilinomethyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.2%

Boc-Tra-Phe-CH2Cl (152438-35-2) + p-aminoethylbenzoate (94-09-7) → Boc-Tra-Phe-4-ethoxycarbonylanilinomethyl ketone (152438-45-4)

Guidance literature:

With sodium hydrogencarbonate; sodium iodide; In N,N-dimethyl-formamide; at 45 ℃; for 48h;

DOI:10.1248/cpb.41.1079

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → Boc-Tra-Phe-4-ethoxycarbonylanilinomethyl ketone (152438-45-4)

Guidance literature:

Multi-step reaction with 5 steps

1: Et₃N

2: 2.) 7.6 N HCl / 1.) THF, 4 deg C, 5 h, 2.) THF, dioxane, -15 deg C, 3 h

3: 7.0 N HCl / dioxane

4: 54.7 percent / Et₃N / tetrahydrofuran; dimethylformamide / 4 °C

5: 6.2 percent / NaI, NaHCO₃ / dimethylformamide / 48 h / 45 °C

With hydrogenchloride; sodium hydrogencarbonate; triethylamine; sodium iodide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.41.1079

Reference yield:

trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid (27687-14-5) → Boc-Tra-Phe-4-ethoxycarbonylanilinomethyl ketone (152438-45-4)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N

2: 54.7 percent / Et₃N / tetrahydrofuran; dimethylformamide / 4 °C

3: 6.2 percent / NaI, NaHCO₃ / dimethylformamide / 48 h / 45 °C

With sodium hydrogencarbonate; triethylamine; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1248/cpb.41.1079

upstream raw materials:

Boc-Tra-Phe-CH₂Cl

p-aminoethylbenzoate

N-tert-butoxycarbonyl-L-phenylalanine

trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid