C₃₀H₁₈Cl₃F₃N₂O₆

Base Information

• Chemical Name: C₃₀H₁₈Cl₃F₃N₂O₆
• CAS No.: 1443038-13-8
• Molecular Formula: C₃₀H₁₈Cl₃F₃N₂O₆
• Molecular Weight: 665.837
• Mol file: 1443038-13-8.mol

Synonyms:C₃₀H₁₈Cl₃F₃N₂O₆

Chemical Property of C₃₀H₁₈Cl₃F₃N₂O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₀H₁₈Cl₃F₃N₂O₆

There total 11 articles about C₃₀H₁₈Cl₃F₃N₂O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

[4-(4-fluorobenzoyl)-2-chloro-6-fluorophenoxy]ethanoic acid (1443038-02-5) + 2-(2-chloro-4-(4-chlorobenzoyl)-6-fluorophenoxy)acetohydrazide (1443038-08-1) → C30H18Cl3F3N2O6 (1443038-13-8)

Guidance literature:

With 2,6-dimethylpyridine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/j.ejmech.2013.02.040

Reference yield:

2-chloro-6-fluorophenol (2040-90-6) → C30H18Cl3F3N2O6 (1443038-13-8)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

2: aluminum (III) chloride / 1 h / 150 °C

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

4: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

5: 2,6-dimethylpyridine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 12 h / 20 °C

With 2,6-dimethylpyridine; aluminum (III) chloride; water; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: |Fries Phenol Ester Rearrangement;

DOI:10.1016/j.ejmech.2013.02.040

Reference yield:

4-chloro-benzoic acid 2-chloro-6-fluoro-phenyl ester (1443037-88-4) → C30H18Cl3F3N2O6 (1443038-13-8)

Guidance literature:

Multi-step reaction with 5 steps

1: aluminum (III) chloride / 1 h / 150 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

3: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

4: hydrazine hydrate / ethanol / 1 h / 0 °C

5: 2,6-dimethylpyridine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 12 h / 20 °C

With 2,6-dimethylpyridine; aluminum (III) chloride; water; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 1: |Fries Phenol Ester Rearrangement;

DOI:10.1016/j.ejmech.2013.02.040

upstream raw materials:

2-chloro-6-fluorophenyl-4-fluorobenzoate

4-chloro-benzoic acid 2-chloro-6-fluoro-phenyl ester

(3-chloro-5-fluoro-4-hydroxyphenyl)-4-fluorophenyl methanone

(3-chloro-5-fluoro-4-hydroxy-phenyl)-(4-chloro-phenyl)-methanone

Downstream raw materials:

C₃₀H₁₆Cl₃F₃N₂O₅