[4-(4-fluorobenzoyl)-2-chloro-6-fluorophenoxy]ethanoic acid

Base Information

• Chemical Name: [4-(4-fluorobenzoyl)-2-chloro-6-fluorophenoxy]ethanoic acid
• CAS No.: 1443038-02-5
• Molecular Formula: C₁₅H₉ClF₂O₄
• Molecular Weight: 326.684
• Mol file: 1443038-02-5.mol

Synonyms:[4-(4-fluorobenzoyl)-2-chloro-6-fluorophenoxy]ethanoic acid

Chemical Property of [4-(4-fluorobenzoyl)-2-chloro-6-fluorophenoxy]ethanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-(4-fluorobenzoyl)-2-chloro-6-fluorophenoxy]ethanoic acid

There total 5 articles about [4-(4-fluorobenzoyl)-2-chloro-6-fluorophenoxy]ethanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl [2-(4-fluorobenzoyl)-2-chloro-6-fluorophenoxy]acetate (1443037-97-5) → [4-(4-fluorobenzoyl)-2-chloro-6-fluorophenoxy]ethanoic acid (1443038-02-5)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1016/j.ejmech.2013.02.040

Reference yield:

2-chloro-6-fluorophenyl-4-fluorobenzoate (1443037-87-3) → [4-(4-fluorobenzoyl)-2-chloro-6-fluorophenoxy]ethanoic acid (1443038-02-5)

Guidance literature:

Multi-step reaction with 3 steps

1: aluminum (III) chloride / 1 h / 150 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

3: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

With aluminum (III) chloride; water; potassium carbonate; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; 1: |Fries Phenol Ester Rearrangement;

DOI:10.1016/j.ejmech.2013.02.040

Reference yield:

(3-chloro-5-fluoro-4-hydroxyphenyl)-4-fluorophenyl methanone (1443037-92-0) → [4-(4-fluorobenzoyl)-2-chloro-6-fluorophenoxy]ethanoic acid (1443038-02-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

2: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

With water; potassium carbonate; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2013.02.040

upstream raw materials:

2-chloro-6-fluorophenyl-4-fluorobenzoate

(3-chloro-5-fluoro-4-hydroxyphenyl)-4-fluorophenyl methanone

ethyl [2-(4-fluorobenzoyl)-2-chloro-6-fluorophenoxy]acetate

4-fluorobenzoyl chloride

Downstream raw materials:

[2-chloro-6-fluoro-4-(4-fluoro-benzoyl)-phenoxy]acetic acid hydrazide

N,N-di[di(2-chloro-6-fluoro-4-(4-fluoro-benzoyl)phenoxy)]acetyl hydrazide

2,5-di[2-fluoro-4-(4-fluoro)benzoyl-6-chlorophenoxymethyl]-1,3,4-oxadiazole

C₃₀H₁₈Cl₃F₃N₂O₆