(3-chloro-5-fluoro-4-hydroxyphenyl)-4-fluorophenyl methanone

Base Information

• Chemical Name: (3-chloro-5-fluoro-4-hydroxyphenyl)-4-fluorophenyl methanone
• CAS No.: 1443037-92-0
• Molecular Formula: C₁₃H₇ClF₂O₂
• Molecular Weight: 268.647
• Mol file: 1443037-92-0.mol

Synonyms:(3-chloro-5-fluoro-4-hydroxyphenyl)-4-fluorophenyl methanone

Chemical Property of (3-chloro-5-fluoro-4-hydroxyphenyl)-4-fluorophenyl methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-chloro-5-fluoro-4-hydroxyphenyl)-4-fluorophenyl methanone

There total 3 articles about (3-chloro-5-fluoro-4-hydroxyphenyl)-4-fluorophenyl methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-chloro-6-fluorophenyl-4-fluorobenzoate (1443037-87-3) → (3-chloro-5-fluoro-4-hydroxyphenyl)-4-fluorophenyl methanone (1443037-92-0)

Guidance literature:

With aluminum (III) chloride; at 150 ℃;

DOI:10.1016/j.bioorg.2016.02.001

Reference yield:

4-fluorobenzoyl chloride (403-43-0) → (3-chloro-5-fluoro-4-hydroxyphenyl)-4-fluorophenyl methanone (1443037-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

2: aluminum (III) chloride / 1 h / 150 °C

With aluminum (III) chloride; triethylamine; In dichloromethane; 2: |Fries Phenol Ester Rearrangement;

DOI:10.1016/j.ejmech.2013.02.040

Reference yield:

2-chloro-6-fluorophenol (2040-90-6) → (3-chloro-5-fluoro-4-hydroxyphenyl)-4-fluorophenyl methanone (1443037-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

2: aluminum (III) chloride / 1 h / 150 °C

With aluminum (III) chloride; triethylamine; In dichloromethane; 2: |Fries Phenol Ester Rearrangement;

DOI:10.1016/j.ejmech.2013.02.040

upstream raw materials:

2-chloro-6-fluorophenyl-4-fluorobenzoate

4-fluorobenzoyl chloride

2-chloro-6-fluorophenol

Downstream raw materials:

[4-(4-fluorobenzoyl)-2-chloro-6-fluorophenoxy]ethanoic acid

[2-chloro-6-fluoro-4-(4-fluoro-benzoyl)-phenoxy]acetic acid hydrazide

N,N-di[di(2-chloro-6-fluoro-4-(4-fluoro-benzoyl)phenoxy)]acetyl hydrazide

C₃₀H₁₈Cl₃F₃N₂O₆