(1S(R),2S)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methyl-2-fluoropropionamide

Base Information

Chemical Name:(1S(R),2S)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methyl-2-fluoropropionamide
CAS No.:198779-12-3
Molecular Formula:C₁₃H₁₈FNO₂
Molecular Weight:239.29
Hs Code.:

Synonyms:(1S(R),2S)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methyl-2-fluoropropionamide

Suppliers and Price of (1S(R),2S)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methyl-2-fluoropropionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S(R),2S)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methyl-2-fluoropropionamide

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Technology Process of (1S(R),2S)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methyl-2-fluoropropionamide

There total 2 articles about (1S(R),2S)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methyl-2-fluoropropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 204323-36-4
(1S,2S)-pseudoephedrine α-fluoroacetamide

: 74-88-4
methyl iodide

: 198779-12-3
(1S(R),2S)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methyl-2-fluoropropionamide

Guidance literature:: With n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; lithium chloride; In tetrahydrofuran; hexane; at -50 ℃; for 0.5h;
DOI:10.1016/S0040-4039(98)00152-X

Reference yield:

: 90-82-4,7009-81-6,90-83-5,6912-63-6
pseudoephedrine

: 198779-12-3
(1S(R),2S)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methyl-2-fluoropropionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / various solvent(s) / 2 h / Heating

2: 92 percent / LiCl, bis(trimethylsilyl)amine, n-BuLi / tetrahydrofuran; hexane / 0.5 h / -50 °C

With n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; lithium chloride; In tetrahydrofuran; hexane;
DOI:10.1016/S0040-4039(98)00152-X