2-(2',3'-dichloro-benzylidene)-3-oxo-butyric acid butyryloxymethyl ester

Base Information

• Chemical Name: 2-(2',3'-dichloro-benzylidene)-3-oxo-butyric acid butyryloxymethyl ester
• CAS No.: 1020718-27-7
• Molecular Formula: C₁₆H₁₆Cl₂O₅
• Molecular Weight: 359.206
• Mol file: 1020718-27-7.mol

Synonyms:2-(2',3'-dichloro-benzylidene)-3-oxo-butyric acid butyryloxymethyl ester

Chemical Property of 2-(2',3'-dichloro-benzylidene)-3-oxo-butyric acid butyryloxymethyl ester

Chemical Property:

Purity/Quality:

98% HPLC ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2',3'-dichloro-benzylidene)-3-oxo-butyric acid butyryloxymethyl ester

There total 5 articles about 2-(2',3'-dichloro-benzylidene)-3-oxo-butyric acid butyryloxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloromethyl n-butyrate (33657-49-7) + 2-acetyl-3-(2',3'-dichlorophenyl)prop-2-enoic acid, potassium salt (1346644-00-5) → 2-(2',3'-dichloro-benzylidene)-3-oxo-butyric acid butyryloxymethyl ester (1020718-27-7)

Guidance literature:

With triethylamine; In dichloromethane; at 25 - 42 ℃; for 30h; Inert atmosphere;

Reference yield:

chloromethyl n-butyrate (33657-49-7) + 2-acetyl-3-(2',3'-dichlorophenyl)prop-2-enoic acid (404373-25-7) → 2-(2',3'-dichloro-benzylidene)-3-oxo-butyric acid butyryloxymethyl ester (1020718-27-7)

Guidance literature:

With triethylamine; In dichloromethane; at 25 - 45 ℃; for 35h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

2,3-dichlorobenzylaldehyde (6334-18-5) → 2-(2',3'-dichloro-benzylidene)-3-oxo-butyric acid butyryloxymethyl ester (1020718-27-7)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine / isopropyl alcohol; acetic acid / 18 h / 10 - 50 °C

2: formic acid / 8.5 h / 25 - 50 °C

3: triethylamine / dichloromethane / 35 h / 25 - 45 °C / Inert atmosphere

With piperidine; formic acid; triethylamine; In dichloromethane; acetic acid; isopropyl alcohol;

upstream raw materials:

2,3-dichlorobenzylaldehyde

chloromethyl n-butyrate

2-acetyl-3-(2',3'-dichlorophenyl)prop-2-enoic acid

2-acetyl-3-(2',3'-dichlorophenyl)prop-2-enoic acid, potassium salt

Downstream raw materials:

clevidipine

Refernces