1-[1-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-phenylethyl]-1H-1,2,3-benzotriazole

Base Information

Chemical Name:1-[1-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-phenylethyl]-1H-1,2,3-benzotriazole
CAS No.:333381-98-9
Molecular Formula:C₂₄H₂₀N₄O₂
Molecular Weight:396.448
Hs Code.:

Synonyms:1-[1-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-phenylethyl]-1H-1,2,3-benzotriazole

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Chemical Property of 1-[1-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-phenylethyl]-1H-1,2,3-benzotriazole

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Technology Process of 1-[1-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-phenylethyl]-1H-1,2,3-benzotriazole

There total 3 articles about 1-[1-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-phenylethyl]-1H-1,2,3-benzotriazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 100-39-0
benzyl bromide

: 305860-85-9
1-[[3-(4-methoxyphenyl)-5-isoxazolyl]methyl]-1H-1,2,3-benzotriazole

: 333381-98-9
1-[1-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-phenylethyl]-1H-1,2,3-benzotriazole

Guidance literature:: 1-[[3-(4-methoxyphenyl)-5-isoxazolyl]methyl]-1H-1,2,3-benzotriazole; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

benzyl bromide; In tetrahydrofuran; at 20 ℃;
DOI:10.1002/jhet.5570370616

Reference yield:

: 95-14-7,27556-51-0
1,2,3-Benzotriazole

: 333381-98-9
1-[1-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-phenylethyl]-1H-1,2,3-benzotriazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 0.67 h / 0 - 20 °C

1.2: 70 percent / dimethylformamide / 2 h / 20 °C

2.1: 95 percent / KHCO₃; NCS; H₂O / ethyl acetate / 23 h / Heating

3.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

3.2: 76 percent / tetrahydrofuran / 20 °C

With N-chloro-succinimide; water; sodium hydride; potassium hydrogencarbonate; lithium diisopropyl amide; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570370616

Reference yield:

: 142321-23-1
1-(1H-benzotriazol-1-yl)prop-2-yne

: 333381-98-9
1-[1-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-phenylethyl]-1H-1,2,3-benzotriazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95 percent / KHCO₃; NCS; H₂O / ethyl acetate / 23 h / Heating

2.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

2.2: 76 percent / tetrahydrofuran / 20 °C

With N-chloro-succinimide; water; potassium hydrogencarbonate; lithium diisopropyl amide; In tetrahydrofuran; ethyl acetate;
DOI:10.1002/jhet.5570370616