N-((2-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl)-2-methoxyethanamine

Base Information

Chemical Name:N-((2-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl)-2-methoxyethanamine
CAS No.:1127329-23-0
Molecular Formula:C₂₁H₂₀FN₅O₄S
Molecular Weight:457.485
Hs Code.:

Synonyms:N-((2-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl)-2-methoxyethanamine

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Chemical Property of N-((2-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl)-2-methoxyethanamine

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Technology Process of N-((2-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl)-2-methoxyethanamine

There total 7 articles about N-((2-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl)-2-methoxyethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1127329-22-9
2-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazole-5-carbaldehyde

: 109-85-3
2-methoxyethylamine

: 1127329-23-0
N-((2-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl)-2-methoxyethanamine

Guidance literature:: 2-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazole-5-carbaldehyde; 2-methoxyethylamine; With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 24h;

With water; sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 39021-62-0
1-methylimidazole-5-carbaldehyde

: 1127329-23-0
N-((2-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl)-2-methoxyethanamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: camphor-10-sulfonic acid / toluene / 24 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexanes / 0.33 h / -78 °C

2.2: -78 °C

3.1: n-butyllithium / tetrahydrofuran; hexanes / 0.17 h / -78 °C

3.2: -78 - 20 °C

3.3: 4 h / Reflux; Inert atmosphere

4.1: sodium hydrogencarbonate / diphenylether / 4 h / 180 °C

5.1: camphor-10-sulfonic acid / 5 h / Reflux

6.1: hydrogenchloride; water / acetone / 20 °C

7.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 24 h / 20 °C

With hydrogenchloride; n-butyllithium; water; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; camphor-10-sulfonic acid; In tetrahydrofuran; hexanes; diphenylether; dichloromethane; acetone; toluene;

Reference yield:

: 1127329-18-3
5-(1,3-dioxan-2-yl)-2-iodo-1-methyl-1H-imidazole

: 1127329-23-0
N-((2-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl)-2-methoxyethanamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 0.17 h / -78 °C

1.2: -78 - 20 °C

1.3: 4 h / Reflux; Inert atmosphere

2.1: sodium hydrogencarbonate / diphenylether / 4 h / 180 °C

3.1: camphor-10-sulfonic acid / 5 h / Reflux

4.1: hydrogenchloride; water / acetone / 20 °C

5.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 24 h / 20 °C

With hydrogenchloride; n-butyllithium; water; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; camphor-10-sulfonic acid; In tetrahydrofuran; hexanes; diphenylether; dichloromethane; acetone;