(S)-2-hydroxy-2-methyl-4-phenylthiobutyronitrile

Base Information

• Chemical Name: (S)-2-hydroxy-2-methyl-4-phenylthiobutyronitrile
• CAS No.: 691890-02-5
• Molecular Formula: C₁₁H₁₃NOS
• Molecular Weight: 207.296
• Mol file: 691890-02-5.mol

Synonyms:(S)-2-hydroxy-2-methyl-4-phenylthiobutyronitrile

Chemical Property of (S)-2-hydroxy-2-methyl-4-phenylthiobutyronitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-2-hydroxy-2-methyl-4-phenylthiobutyronitrile

There total 2 articles about (S)-2-hydroxy-2-methyl-4-phenylthiobutyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

hydrogen cyanide (74-90-8) + 4-phenylsulfanyl-butan-2-one (6110-01-6) → (S)-2-hydroxy-2-methyl-4-phenylthiobutyronitrile (691890-02-5)

Guidance literature:

With dipotassium hydrogenphosphate; citric acid; In water; at 0 ℃; pH=6.0; Enzymatic reaction;

DOI:10.1002/chem.200601114

Reference yield:

thiophenol (108-98-5) → (S)-2-hydroxy-2-methyl-4-phenylthiobutyronitrile (691890-02-5)

Guidance literature:

Multi-step reaction with 2 steps

1: trimethylamine / various solvent(s) / 0 °C

2: K₂HPO₄; citric acid; hydroxynitrile lyase from Hevea brasiliensis (HbHNL) / H₂O; various solvent(s) / 0 °C / pH 6.0 / Enzymatic reaction

With dipotassium hydrogenphosphate; citric acid; trimethylamine; In water; 1: Michael addition;

DOI:10.1002/chem.200601114

Reference yield: 65.0%

(S)-2-hydroxy-2-methyl-4-phenylthiobutyronitrile (691890-02-5) → (S)-2-hydroxy-2-methyl-4-(phenylthio)butanoic acid (691359-47-4)

Guidance literature:

With hydrogenchloride; water; at 85 ℃; for 16h;

DOI:10.1002/chem.200601114

upstream raw materials:

hydrogen cyanide

4-phenylsulfanyl-butan-2-one

thiophenol

Downstream raw materials:

(S)-2-hydroxy-2-methyl-4-(phenylthio)butanoic acid

(S)-2-hydroxy-2-methylbutyric acid

Refernces