(E)-ethyl 2-(cyanomethyl)-3-(3-nitro-4'-(pyrrolidine-1-carbonyl)biphenyl-4-yl)acrylate

Base Information

Chemical Name:(E)-ethyl 2-(cyanomethyl)-3-(3-nitro-4'-(pyrrolidine-1-carbonyl)biphenyl-4-yl)acrylate
CAS No.:1268163-45-6
Molecular Formula:C₂₄H₂₃N₃O₅
Molecular Weight:433.464
Hs Code.:

Synonyms:(E)-ethyl 2-(cyanomethyl)-3-(3-nitro-4'-(pyrrolidine-1-carbonyl)biphenyl-4-yl)acrylate

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Chemical Property of (E)-ethyl 2-(cyanomethyl)-3-(3-nitro-4'-(pyrrolidine-1-carbonyl)biphenyl-4-yl)acrylate

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Technology Process of (E)-ethyl 2-(cyanomethyl)-3-(3-nitro-4'-(pyrrolidine-1-carbonyl)biphenyl-4-yl)acrylate

There total 1 articles about (E)-ethyl 2-(cyanomethyl)-3-(3-nitro-4'-(pyrrolidine-1-carbonyl)biphenyl-4-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 389621-81-2
[4-(pyrrolidin-1-ylcarbonyl)phenyl]boronic acid

: 1268163-45-6
(E)-ethyl 2-(cyanomethyl)-3-(3-nitro-4'-(pyrrolidine-1-carbonyl)biphenyl-4-yl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 18 h / 100 °C

2: toluene / 2.5 h / Reflux

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene;

Reference yield:

: 1268163-45-6
(E)-ethyl 2-(cyanomethyl)-3-(3-nitro-4'-(pyrrolidine-1-carbonyl)biphenyl-4-yl)acrylate

: 926927-54-0
(1E,4E)-ethyl 2-amino-8-[4-(pyrrolidine-1-carbonyl)-phenyl]-3H-benzo[b]azepine-4-carboxylate

Guidance literature:: (E)-ethyl 2-(cyanomethyl)-3-(3-nitro-4'-(pyrrolidine-1-carbonyl)biphenyl-4-yl)acrylate; With iron; acetic acid; at 85 ℃; for 4h;

With sodium carbonate; In water; pH=9 - 10;

Reference yield:

: 1268163-45-6
(E)-ethyl 2-(cyanomethyl)-3-(3-nitro-4'-(pyrrolidine-1-carbonyl)biphenyl-4-yl)acrylate

: 926927-58-4
(1E,4E)-ethyl-2-(tert-butoxycarbonylamino)-8-[4-(pyrrolidine-1-carbonyl)-phenyl]-3H-benzo[b]azepine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; iron / 4 h / 85 °C

1.2: pH 9 - 10

2.1: dichloromethane / 72 h / 20 °C

With iron; acetic acid; In dichloromethane;