(4-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperazin-1-yl)(pyridin-4-yl)methanone

Base Information

Chemical Name:(4-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperazin-1-yl)(pyridin-4-yl)methanone
CAS No.:1345404-16-1
Molecular Formula:C₂₄H₂₃N₅OS
Molecular Weight:429.546
Hs Code.:

Synonyms:(4-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperazin-1-yl)(pyridin-4-yl)methanone

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Chemical Property of (4-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperazin-1-yl)(pyridin-4-yl)methanone

Chemical Property:

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Technology Process of (4-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperazin-1-yl)(pyridin-4-yl)methanone

There total 7 articles about (4-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperazin-1-yl)(pyridin-4-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55-22-1
pyridine-4-carboxylic acid

: 1345403-93-1
3-(methylsulfanyl)-1-phenyl-6-piperazin-1-yl-1H-indazole hydrochloride

: 1345404-16-1
(4-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperazin-1-yl)(pyridin-4-yl)methanone

Guidance literature:: pyridine-4-carboxylic acid; 3-(methylsulfanyl)-1-phenyl-6-piperazin-1-yl-1H-indazole hydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 20776-50-5
2-amino-4-bromobenzoic acid

: 1345404-16-1
(4-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperazin-1-yl)(pyridin-4-yl)methanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

1.3: pH 7

2.1: hydrogenchloride; sodium nitrite / ethanol; water / 76 °C

3.1: tetraphosphorus decasulfide / xylene / 1 h / 130 °C

4.1: caesium carbonate / acetonitrile / 20 °C

5.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / Reflux

6.1: hydrogenchloride / dichloromethane / 0 - 20 °C

7.1: triethylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

7.2: 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; tetraphosphorus decasulfide; caesium carbonate; triethylamine; 1,1'-carbonyldiimidazole; sodium nitrite; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; xylene;

Reference yield:

: 1345403-94-2
2-Amino-4-bromo-benzoic acid N'-phenyl-hydrazide

: 1345404-16-1
(4-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperazin-1-yl)(pyridin-4-yl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; sodium nitrite / ethanol; water / 76 °C

2.1: tetraphosphorus decasulfide / xylene / 1 h / 130 °C

3.1: caesium carbonate / acetonitrile / 20 °C

4.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / Reflux

5.1: hydrogenchloride / dichloromethane / 0 - 20 °C

6.1: triethylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

6.2: 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; tetraphosphorus decasulfide; caesium carbonate; triethylamine; sodium nitrite; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; xylene;