4-(3-Methylsulfanyl-1-phenyl-1H-indazol-6-yl)-piperazine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(3-Methylsulfanyl-1-phenyl-1H-indazol-6-yl)-piperazine-1-carboxylic acid tert-butyl ester
CAS No.:1345403-96-4
Molecular Formula:C₂₃H₂₈N₄O₂S
Molecular Weight:424.567
Hs Code.:

Synonyms:4-(3-Methylsulfanyl-1-phenyl-1H-indazol-6-yl)-piperazine-1-carboxylic acid tert-butyl ester

Suppliers and Price of 4-(3-Methylsulfanyl-1-phenyl-1H-indazol-6-yl)-piperazine-1-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(3-Methylsulfanyl-1-phenyl-1H-indazol-6-yl)-piperazine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(3-Methylsulfanyl-1-phenyl-1H-indazol-6-yl)-piperazine-1-carboxylic acid tert-butyl ester

There total 6 articles about 4-(3-Methylsulfanyl-1-phenyl-1H-indazol-6-yl)-piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332527-04-4
6-Bromo-3-methylsulfanyl-1-phenyl-1H-indazole

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1345403-96-4
4-(3-Methylsulfanyl-1-phenyl-1H-indazol-6-yl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; Reflux;
DOI:10.1016/j.bmcl.2011.06.067

Reference yield:

: 1332526-99-4
6-Bromo-1-phenyl-1,2-dihydro-indazol-3-one

: 1345403-96-4
4-(3-Methylsulfanyl-1-phenyl-1H-indazol-6-yl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetraphosphorus decasulfide / 5,5-dimethyl-1,3-cyclohexadiene / 130 °C

2: caesium carbonate

3: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / Reflux

With tetraphosphorus decasulfide; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 5,5-dimethyl-1,3-cyclohexadiene; toluene; 3: Buchwald amination;
DOI:10.1016/j.bmcl.2011.06.067

Reference yield:

: 1345403-94-2
2-Amino-4-bromo-benzoic acid N'-phenyl-hydrazide

: 1345403-96-4
4-(3-Methylsulfanyl-1-phenyl-1H-indazol-6-yl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; sodium nitrite / ethanol; water / 76 °C

2: tetraphosphorus decasulfide / xylene / 1 h / 130 °C

3: caesium carbonate / acetonitrile / 20 °C

4: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / Reflux

With hydrogenchloride; tetraphosphorus decasulfide; caesium carbonate; sodium nitrite; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In ethanol; water; toluene; acetonitrile; xylene;