N-(5-bromo-2-(4-(thiophen-2-carbonyl)piperazin-1-yl)phenyl)-2-(phenylimino)-2H-chromene-3-carboxamide

Base Information

• Chemical Name: N-(5-bromo-2-(4-(thiophen-2-carbonyl)piperazin-1-yl)phenyl)-2-(phenylimino)-2H-chromene-3-carboxamide
• CAS No.: 1429200-37-2
• Molecular Formula: C₃₁H₂₅BrN₄O₃S
• Molecular Weight: 613.534

Synonyms:N-(5-bromo-2-(4-(thiophen-2-carbonyl)piperazin-1-yl)phenyl)-2-(phenylimino)-2H-chromene-3-carboxamide

Chemical Property of N-(5-bromo-2-(4-(thiophen-2-carbonyl)piperazin-1-yl)phenyl)-2-(phenylimino)-2H-chromene-3-carboxamide

Chemical Property:

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Technology Process of N-(5-bromo-2-(4-(thiophen-2-carbonyl)piperazin-1-yl)phenyl)-2-(phenylimino)-2H-chromene-3-carboxamide

There total 9 articles about N-(5-bromo-2-(4-(thiophen-2-carbonyl)piperazin-1-yl)phenyl)-2-(phenylimino)-2H-chromene-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-Thiophenecarbonyl chloride (5271-67-0) + N-(5-bromo-2-(piperazin-1-yl)phenyl)-2-(phenylimino)-2H-chromene-3-carboxamide (1429200-13-4) → N-(5-bromo-2-(4-(thiophen-2-carbonyl)piperazin-1-yl)phenyl)-2-(phenylimino)-2H-chromene-3-carboxamide (1429200-37-2)

Guidance literature:

With potassium carbonate; In toluene; Inert atmosphere; Reflux;

DOI:10.1016/j.bmc.2013.01.064

Reference yield:

N-(2-(4-tert-butoxycarbonylpiperazin-1-yl)-5-bromophenyl)-2-cyanoacetamide (1429200-01-0) → N-(5-bromo-2-(4-(thiophen-2-carbonyl)piperazin-1-yl)phenyl)-2-(phenylimino)-2H-chromene-3-carboxamide (1429200-37-2)

Guidance literature:

Multi-step reaction with 4 steps

1: piperidine / methanol / 7 h / 50 °C

2: methanol / Reflux; Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 12 h / 0 - 20 °C

4: potassium carbonate / toluene / Inert atmosphere; Reflux

With piperidine; potassium carbonate; trifluoroacetic acid; In methanol; dichloromethane; toluene;

DOI:10.1016/j.bmc.2013.01.064

Reference yield:

aniline (62-53-3) → N-(5-bromo-2-(4-(thiophen-2-carbonyl)piperazin-1-yl)phenyl)-2-(phenylimino)-2H-chromene-3-carboxamide (1429200-37-2)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / diethyl ether / 20 °C

2: methanol / Reflux; Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 12 h / 0 - 20 °C

4: potassium carbonate / toluene / Inert atmosphere; Reflux

With hydrogenchloride; potassium carbonate; trifluoroacetic acid; In methanol; diethyl ether; dichloromethane; toluene;

DOI:10.1016/j.bmc.2013.01.064

upstream raw materials:

N-(2-(4-tert-butoxycarbonylpiperazin-1-yl)-5-bromophenyl)-2-cyanoacetamide

N-(2-(4-tert-butoxycarbonyl-piperazin-1-yl)-5-bromophenyl)-2-imino-2H-chromene-3-carboxamide

1,4-dibromo-2-nitrobenzene

aniline

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