(R)-N-(1-(4-bromophenyl)ethyl)-P,P-diphenylphosphinic amide

Base Information

Chemical Name:(R)-N-(1-(4-bromophenyl)ethyl)-P,P-diphenylphosphinic amide
CAS No.:1207166-21-9
Molecular Formula:C₂₀H₁₉BrNOP
Molecular Weight:400.255
Hs Code.:

Synonyms:(R)-N-(1-(4-bromophenyl)ethyl)-P,P-diphenylphosphinic amide

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Chemical Property of (R)-N-(1-(4-bromophenyl)ethyl)-P,P-diphenylphosphinic amide

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Technology Process of (R)-N-(1-(4-bromophenyl)ethyl)-P,P-diphenylphosphinic amide

There total 4 articles about (R)-N-(1-(4-bromophenyl)ethyl)-P,P-diphenylphosphinic amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 921936-90-5
P,P-diphenyl-N-[1-(4-bromophenyl)ethylidene]phosphinic amide

: 1207166-21-9
(R)-N-(1-(4-bromophenyl)ethyl)-P,P-diphenylphosphinic amide

Guidance literature:: With (S,S)-N,N'-bis[o-(diphenylphosphino)benzylidene]-1,2-diaminocyclohexane; [NEt₃H][HFe₃(CO)₁₁]; potassium hydroxide; In isopropyl alcohol; at 20 - 45 ℃; for 1h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201002456

Reference yield:

: 99-90-1
para-bromoacetophenone

: 1207166-21-9
(R)-N-(1-(4-bromophenyl)ethyl)-P,P-diphenylphosphinic amide

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium acetate / methanol / Inert atmosphere

2: triethylamine / hexane; dichloromethane / Inert atmosphere

3: (Fe(CO)(Ph₂PCH=CHN-((S,S)-CH(Ph)CH(Ph))-NCH=CHPPh₂)); potassium tert-butylate / isopropyl alcohol / 0.75 h / 30 °C / Inert atmosphere; Glovebox

With (Fe(CO)(Ph₂PCH=CHN-((S,S)-CH(Ph)CH(Ph))-NCH=CHPPh₂)); hydroxylamine hydrochloride; potassium tert-butylate; sodium acetate; triethylamine; In methanol; hexane; dichloromethane; isopropyl alcohol;
DOI:10.1021/ol302079q

Reference yield:

: 59862-55-4,73744-33-9,5798-71-0
p-bromoacetophenone oxime

: 1207166-21-9
(R)-N-(1-(4-bromophenyl)ethyl)-P,P-diphenylphosphinic amide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / hexane; dichloromethane / Inert atmosphere

2: (Fe(CO)(Ph₂PCH=CHN-((S,S)-CH(Ph)CH(Ph))-NCH=CHPPh₂)); potassium tert-butylate / isopropyl alcohol / 0.75 h / 30 °C / Inert atmosphere; Glovebox

With (Fe(CO)(Ph₂PCH=CHN-((S,S)-CH(Ph)CH(Ph))-NCH=CHPPh₂)); potassium tert-butylate; triethylamine; In hexane; dichloromethane; isopropyl alcohol;
DOI:10.1021/ol302079q