(1S,2R)-2-{5-chloro-2-[4-(4-piperazin-1-yl-piperidin-1-yl)-phenylamino]-pyrimidin-4-ylamino}-cyclopentanecarboxylic acid isopropylamide

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Chemical Name:(1S,2R)-2-{5-chloro-2-[4-(4-piperazin-1-yl-piperidin-1-yl)-phenylamino]-pyrimidin-4-ylamino}-cyclopentanecarboxylic acid isopropylamide
CAS No.:1036488-26-2
Molecular Formula:C₂₈H₄₁ClN₈O
Molecular Weight:541.14
Hs Code.:

Synonyms:(1S,2R)-2-{5-chloro-2-[4-(4-piperazin-1-yl-piperidin-1-yl)-phenylamino]-pyrimidin-4-ylamino}-cyclopentanecarboxylic acid isopropylamide

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Chemical Property of (1S,2R)-2-{5-chloro-2-[4-(4-piperazin-1-yl-piperidin-1-yl)-phenylamino]-pyrimidin-4-ylamino}-cyclopentanecarboxylic acid isopropylamide

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Technology Process of (1S,2R)-2-{5-chloro-2-[4-(4-piperazin-1-yl-piperidin-1-yl)-phenylamino]-pyrimidin-4-ylamino}-cyclopentanecarboxylic acid isopropylamide

There total 1 articles about (1S,2R)-2-{5-chloro-2-[4-(4-piperazin-1-yl-piperidin-1-yl)-phenylamino]-pyrimidin-4-ylamino}-cyclopentanecarboxylic acid isopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 958227-61-7
(1S,2R)-2-(2,5-dichloro-pyrimidin-4-ylamino)-cyclopentanecarboxylic acid isopropylamide

: 1036488-14-8
tert-butyl 4-[1-(4-amino-phenyl)-piperidin-4-yl]-piperazine-1-carboxylate

: 1036488-26-2
(1S,2R)-2-{5-chloro-2-[4-(4-piperazin-1-yl-piperidin-1-yl)-phenylamino]-pyrimidin-4-ylamino}-cyclopentanecarboxylic acid isopropylamide

Guidance literature:: With hydrogenchloride; methanol; In 1,4-dioxane; at 130 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1036488-26-2
(1S,2R)-2-{5-chloro-2-[4-(4-piperazin-1-yl-piperidin-1-yl)-phenylamino]-pyrimidin-4-ylamino}-cyclopentanecarboxylic acid isopropylamide

: 78-84-2
isobutyraldehyde

: 1036649-28-1
(1S,2R)-2-(5-chloro-2-(4-(4-(4-isobutyl-piperazin-1-yl)-piperidin-1-yl)-phenylamino)-pyrimidin-4-ylamino)-cyclopentanecarboxylic acid isopropylamide

Guidance literature:: (1S,2R)-2-{5-chloro-2-[4-(4-piperazin-1-yl-piperidin-1-yl)-phenylamino]-pyrimidin-4-ylamino}-cyclopentanecarboxylic acid isopropylamide; isobutyraldehyde; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; acetic acid; In N,N-dimethyl-formamide; at 20 ℃; for 16h;