2,2-dimethyl-1-(dimethylphenylsilyl)-3-(tetrahydropyran-2-yloxy)propan-1-ol

Base Information

• Chemical Name: 2,2-dimethyl-1-(dimethylphenylsilyl)-3-(tetrahydropyran-2-yloxy)propan-1-ol
• CAS No.: 266329-36-6
• Molecular Formula: C₁₈H₃₀O₃Si
• Molecular Weight: 322.52
• Mol file: 266329-36-6.mol

Synonyms:2,2-dimethyl-1-(dimethylphenylsilyl)-3-(tetrahydropyran-2-yloxy)propan-1-ol

Chemical Property of 2,2-dimethyl-1-(dimethylphenylsilyl)-3-(tetrahydropyran-2-yloxy)propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-dimethyl-1-(dimethylphenylsilyl)-3-(tetrahydropyran-2-yloxy)propan-1-ol

There total 3 articles about 2,2-dimethyl-1-(dimethylphenylsilyl)-3-(tetrahydropyran-2-yloxy)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

dimethyl(phenyl)silyl lithium (3839-31-4) + 2,2-dimethyl-3-[(tetrahydro-2H-pyran-2-yl)oxy]-propanal (52113-84-5) → 2,2-dimethyl-1-(dimethylphenylsilyl)-3-(tetrahydropyran-2-yloxy)propan-1-ol (266329-36-6)

Guidance literature:

In tetrahydrofuran; at -78 - 0 ℃;

DOI:10.1021/jo9912855

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → 2,2-dimethyl-1-(dimethylphenylsilyl)-3-(tetrahydropyran-2-yloxy)propan-1-ol (266329-36-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / PPTS / CH₂Cl₂ / 20 °C

2: 60 percent / tetrahydrofuran / -78 - 0 °C

With pyridinium p-toluenesulfonate; In tetrahydrofuran; dichloromethane; 1: Addition / 2: Addition;

DOI:10.1021/jo9912855

Reference yield:

2,2-dimethyl-3-hydroxypropionaldehyde (597-31-9) → 2,2-dimethyl-1-(dimethylphenylsilyl)-3-(tetrahydropyran-2-yloxy)propan-1-ol (266329-36-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / PPTS / CH₂Cl₂ / 20 °C

2: 60 percent / tetrahydrofuran / -78 - 0 °C

With pyridinium p-toluenesulfonate; In tetrahydrofuran; dichloromethane; 1: Addition / 2: Addition;

DOI:10.1021/jo9912855

upstream raw materials:

dimethyl(phenyl)silyl lithium

2,2-dimethyl-3-[(tetrahydro-2H-pyran-2-yl)oxy]-propanal

3,4-dihydro-2H-pyran

2,2-dimethyl-3-hydroxypropionaldehyde

Downstream raw materials:

3-bromo-2,2-dimethyl-1-(dimethylphenylsilyl)propan-1-one

1-(dimethylphenylsilyl)-3-methylbutan-1-one

2,2-dimethyl-1-(dimethylphenylsilyl)-3-(tetrahydropyran-2-yloxy)propan-1-one