methyl 2-{[(4-fluorophenyl)methyl]oxy}-5-(4-morpholinylcarbonyl)benzoate

Base Information

Chemical Name:methyl 2-{[(4-fluorophenyl)methyl]oxy}-5-(4-morpholinylcarbonyl)benzoate
CAS No.:1285517-36-3
Molecular Formula:C₂₀H₂₀FNO₅
Molecular Weight:373.381
Hs Code.:

Synonyms:methyl 2-{[(4-fluorophenyl)methyl]oxy}-5-(4-morpholinylcarbonyl)benzoate

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Chemical Property of methyl 2-{[(4-fluorophenyl)methyl]oxy}-5-(4-morpholinylcarbonyl)benzoate

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Technology Process of methyl 2-{[(4-fluorophenyl)methyl]oxy}-5-(4-morpholinylcarbonyl)benzoate

There total 4 articles about methyl 2-{[(4-fluorophenyl)methyl]oxy}-5-(4-morpholinylcarbonyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 30711-03-6
2-hydroxy-5-(morpholine-4-carbonyl)-benzoic acid methyl ester

: 459-46-1
4-Fluorobenzyl bromide

: 1285517-36-3
methyl 2-{[(4-fluorophenyl)methyl]oxy}-5-(4-morpholinylcarbonyl)benzoate

Guidance literature:: With caesium carbonate; In acetone; at 50 ℃; for 2h;

Reference yield:

: 616-76-2
2-hydroxy-5-formylbenzoic acid

: 1285517-36-3
methyl 2-{[(4-fluorophenyl)methyl]oxy}-5-(4-morpholinylcarbonyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 18 h / 50 °C

2: 2-Methyl-1-butene; aminosulfonic acid; sodium chlorite / water; dimethyl sulfoxide; tetrahydrofuran / 0.75 h / 0 °C

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 20 °C

4: caesium carbonate / acetone / 2 h / 50 °C

With sodium chlorite; sulfuric acid; aminosulfonic acid; benzotriazol-1-ol; caesium carbonate; 2-Methyl-1-butene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

Reference yield:

: 41489-76-3
methyl-5-formyl-2-hydroxybenzoate

: 1285517-36-3
methyl 2-{[(4-fluorophenyl)methyl]oxy}-5-(4-morpholinylcarbonyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 2-Methyl-1-butene; aminosulfonic acid; sodium chlorite / water; dimethyl sulfoxide; tetrahydrofuran / 0.75 h / 0 °C

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 20 °C

3: caesium carbonate / acetone / 2 h / 50 °C

With sodium chlorite; aminosulfonic acid; benzotriazol-1-ol; caesium carbonate; 2-Methyl-1-butene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;