4-(4-bromo-2-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)-2-chloropyrimidine

Base Information

Chemical Name:4-(4-bromo-2-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)-2-chloropyrimidine
CAS No.:1188301-66-7
Molecular Formula:C₁₉H₂₂BrClN₄OSi
Molecular Weight:465.852
Hs Code.:

Synonyms:4-(4-bromo-2-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)-2-chloropyrimidine

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Chemical Property of 4-(4-bromo-2-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)-2-chloropyrimidine

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Technology Process of 4-(4-bromo-2-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)-2-chloropyrimidine

There total 1 articles about 4-(4-bromo-2-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)-2-chloropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1722-12-9,1195939-87-7
2-chloropyrimidine

: 1188302-09-1
4,5-dibromo-1-{[2-(trimethylsilyl)ethoxy]methyl}-2-phenyl-1H-imidazole

: 1188301-66-7
4-(4-bromo-2-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)-2-chloropyrimidine

Guidance literature:: 4,5-dibromo-1-{[2-(trimethylsilyl)ethoxy]methyl}-2-phenyl-1H-imidazole; With n-butyllithium; In hexane; at -78 ℃; for 0.75h;

2-chloropyrimidine; In hexane; at -40 ℃; for 0.333333h;

Reference yield: 98.0%

: 1188301-66-7
4-(4-bromo-2-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)-2-chloropyrimidine

: 141-43-5
ethanolamine

: 1188301-67-8
2-(4-(4-bromo-2-phenyl-(1-((2-trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)pyrimidin-2-ylamino)ethanol

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 1h;

Reference yield:

: 1188301-66-7
4-(4-bromo-2-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)-2-chloropyrimidine

: 2-(4-(4-(6-amino-5-methoxypyridin-3-yl)-2-phenyl-1H-imidazol-5-yl)pyrimidin-2-ylamino)ethanol trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-methyl-pyrrolidin-2-one / 1 h / 120 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; 1,2-dimethoxyethane; water / 0.33 h / 115 °C / Microwave irradiation; Inert atmosphere

2.2: 1 h / 60 °C

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; water;