(S,E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

Base Information

Chemical Name:(S,E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt
CAS No.:1430562-93-8
Molecular Formula:C₂HF₃O₂*C₃₉H₃₆ClFN₄O₆
Molecular Weight:825.213
Hs Code.:

(S,E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

Synonyms:(S,E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

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Chemical Property of (S,E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

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Technology Process of (S,E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

There total 9 articles about (S,E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1430562-78-9
(E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

: 1430562-93-8
(S,E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

: 1430562-97-2
(R,E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

Guidance literature:: With carbon dioxide; In ethanol; diethylamine; at 35 ℃; under 75007.5 Torr; Resolution of racemate;

Reference yield:

: 1430563-90-8
5-bromo-2-(methoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

: 1430562-93-8
(S,E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

: 1430562-97-2
(R,E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydroxide / ethanol; 1,4-dioxane / 0.5 h / 150 °C / Microwave irradiation

2: sodium hydroxide / 1,4-dioxane / 2 h

3: trichlorophosphate; pyridine / 2 h / -15 °C

4: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; 1,4-dioxane / 0.33 h / 130 °C / Inert atmosphere; Microwave irradiation

5: 2 h

6: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 50 °C

7: carbon dioxide / ethanol; diethylamine / 35 °C / 75007.5 Torr / Resolution of racemate

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon dioxide; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; In 1,4-dioxane; ethanol; diethylamine; N,N-dimethyl-formamide;

Reference yield:

: 1430563-91-9
5-bromo-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

: 1430562-93-8
(S,E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

: 1430562-97-2
(R,E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate; pyridine / 2 h / -15 °C

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; 1,4-dioxane / 0.33 h / 130 °C / Inert atmosphere; Microwave irradiation

3: 2 h

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 50 °C

5: carbon dioxide / ethanol; diethylamine / 35 °C / 75007.5 Torr / Resolution of racemate

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon dioxide; potassium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1,4-dioxane; ethanol; diethylamine; N,N-dimethyl-formamide;