tert-butyl (R)-4-(2-benzoyl-1,2-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (R)-4-(2-benzoyl-1,2-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate
CAS No.:939964-31-5
Molecular Formula:C₂₇H₃₂F₃N₃O₄
Molecular Weight:519.564
Hs Code.:

Synonyms:tert-butyl (R)-4-(2-benzoyl-1,2-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

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Chemical Property of tert-butyl (R)-4-(2-benzoyl-1,2-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

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Technology Process of tert-butyl (R)-4-(2-benzoyl-1,2-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

There total 10 articles about tert-butyl (R)-4-(2-benzoyl-1,2-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 939964-18-8
(R)-[3-[1,2]diazepan-1-yl-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester

: 98-88-4
benzoyl chloride

: 939964-31-5
tert-butyl (R)-4-(2-benzoyl-1,2-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2007.01.111

Reference yield:

: 769195-26-8
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

: 939964-31-5
tert-butyl (R)-4-(2-benzoyl-1,2-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / ammonium acetate / methanol / 7 h / Heating

2: 68 percent / H₂; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr

3: 93 percent / CH₂Cl₂ / 3 h / 20 °C

4: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C

5: 90 percent / EDCI; triethylamine / CH₂Cl₂ / 12 h / 20 °C

6: 84 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

With ammonium acetate; lithium hydroxide; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; chloro(1,5-cyclooctadiene)rhodium(I) dimer; In tetrahydrofuran; methanol; dichloromethane; 2,2,2-trifluoroethanol;
DOI:10.1016/j.bmcl.2007.01.111

Reference yield:

: methyl 3-amino-4-(2,4,5-trifluorophenyl)but-2-enoate

: 939964-31-5
tert-butyl (R)-4-(2-benzoyl-1,2-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 68 percent / H₂; (R) chiral ferrocenyl derivative / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 2,2,2-trifluoro-ethanol / 40 h / 50 °C / 5171.62 Torr

2: 93 percent / CH₂Cl₂ / 3 h / 20 °C

3: 99 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 20 °C

4: 90 percent / EDCI; triethylamine / CH₂Cl₂ / 12 h / 20 °C

5: 84 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

With lithium hydroxide; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; chloro(1,5-cyclooctadiene)rhodium(I) dimer; In tetrahydrofuran; methanol; dichloromethane; 2,2,2-trifluoroethanol;
DOI:10.1016/j.bmcl.2007.01.111