{2-[4-(tert-Butoxycarbonylamino-methyl)-2-methoxy-phenoxy]-ethyl}-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

Base Information

• Chemical Name: {2-[4-(tert-Butoxycarbonylamino-methyl)-2-methoxy-phenoxy]-ethyl}-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester
• CAS No.: 1026821-70-4
• Molecular Formula: C₃₁H₃₆N₂O₆
• Molecular Weight: 532.637
• Mol file: 1026821-70-4.mol

Synonyms:{2-[4-(tert-Butoxycarbonylamino-methyl)-2-methoxy-phenoxy]-ethyl}-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

Chemical Property of {2-[4-(tert-Butoxycarbonylamino-methyl)-2-methoxy-phenoxy]-ethyl}-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {2-[4-(tert-Butoxycarbonylamino-methyl)-2-methoxy-phenoxy]-ethyl}-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

There total 5 articles about {2-[4-(tert-Butoxycarbonylamino-methyl)-2-methoxy-phenoxy]-ethyl}-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + [3-Methoxy-4-(2-methylamino-ethoxy)-benzyl]-carbamic acid tert-butyl ester; hydrobromide → {2-[4-(tert-Butoxycarbonylamino-methyl)-2-methoxy-phenoxy]-ethyl}-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester (1026821-70-4)

Guidance literature:

With triethylamine; In 1,4-dioxane; water; for 6h; Ambient temperature;

DOI:10.1021/jm960512h

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → {2-[4-(tert-Butoxycarbonylamino-methyl)-2-methoxy-phenoxy]-ethyl}-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester (1026821-70-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 89 percent / Et₃N / H₂O; dioxane / Ambient temperature

2: 77 percent / 40percent aq. KOH, 40percent aq. tetrabutylammonium hydroxide / 3 h / 50 °C

3: 76 percent / ethanol / 6 h / Heating

4: 93 percent / Et₃N / dioxane; H₂O / 6 h / Ambient temperature

With potassium hydroxide; tetra(n-butyl)ammonium hydroxide; triethylamine; In 1,4-dioxane; ethanol; water;

DOI:10.1021/jm960512h

Reference yield:

vanillylamine hydrochloride (7149-10-2) → {2-[4-(tert-Butoxycarbonylamino-methyl)-2-methoxy-phenoxy]-ethyl}-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester (1026821-70-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 89 percent / Et₃N / H₂O; dioxane / Ambient temperature

2: 77 percent / 40percent aq. KOH, 40percent aq. tetrabutylammonium hydroxide / 3 h / 50 °C

3: 76 percent / ethanol / 6 h / Heating

4: 93 percent / Et₃N / dioxane; H₂O / 6 h / Ambient temperature

With potassium hydroxide; tetra(n-butyl)ammonium hydroxide; triethylamine; In 1,4-dioxane; ethanol; water;

DOI:10.1021/jm960512h

upstream raw materials:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

di-tert-butyl dicarbonate

vanillylamine hydrochloride

(4-hydroxy-3-methoxybenzyl)carbamic acid tert-butyl ester

Downstream raw materials:

[2-(4-{3-[2-(4-Chloro-phenyl)-ethyl]-thioureidomethyl}-2-methoxy-phenoxy)-ethyl]-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester