C₉H₆Br₃FO₂

Base Information

• Chemical Name: C₉H₆Br₃FO₂
• CAS No.: 1359857-64-9
• Molecular Formula: C₉H₆Br₃FO₂
• Molecular Weight: 404.856
• Mol file: 1359857-64-9.mol

Synonyms:C₉H₆Br₃FO₂

Chemical Property of C₉H₆Br₃FO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₉H₆Br₃FO₂

There total 4 articles about C₉H₆Br₃FO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-bromo-6-fluoro-3-methylbenzoic acid methyl ester (1359857-62-7) → C9H6Br3FO2 (1359857-64-9)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 2h; Inert atmosphere; Reflux;

DOI:10.1016/j.bmcl.2011.12.096

Reference yield:

2-bromo-6-fluoro-3-methylbenzaldehyde (154650-16-5) → C9H6Br3FO2 (1359857-64-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 0.5 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 1 h / 20 °C

3.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 2 h / Inert atmosphere; Reflux

With sodium chlorite; N-Bromosuccinimide; 2-methyl-but-2-ene; sodium dihydrogenphosphate dihydrate; potassium carbonate; dibenzoyl peroxide; In tetrachloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/j.bmcl.2011.12.096

Reference yield:

2-bromo-6-fluoro-3-methylbenzoic acid (1359857-60-5) → C9H6Br3FO2 (1359857-64-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 1 h / 20 °C

2.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 2 h / Inert atmosphere; Reflux

With N-Bromosuccinimide; potassium carbonate; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.12.096

upstream raw materials:

2-bromo-6-fluoro-3-methylbenzaldehyde

2-bromo-6-fluoro-3-methylbenzoic acid

2-bromo-6-fluoro-3-methylbenzoic acid methyl ester

2-bromo-4-fluorotoluene

Downstream raw materials:

C₁₂H₁₃BrO₅

C₁₈H₂₅BO₇

C₁₀H₉BrO₄

Refernces