dimethyl 2-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-3,4-dicarboxylate

Base Information

• Chemical Name: dimethyl 2-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-3,4-dicarboxylate
• CAS No.: 1432732-95-0
• Molecular Formula: C₂₃H₂₂O₉
• Molecular Weight: 442.422
• Mol file: 1432732-95-0.mol

Synonyms:dimethyl 2-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-3,4-dicarboxylate

Chemical Property of dimethyl 2-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-3,4-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 2-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-3,4-dicarboxylate

There total 2 articles about dimethyl 2-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-3,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-dimethoxybenzene (91-16-7) + (Z)-4-Methoxy-3-(4-methoxybenzoyl)-2-(methoxycarbonyl)-4-oxobut-2-enoic acid → dimethyl 2-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-3,4-dicarboxylate (1432732-95-0) + dimethyl 3-(3,4-dimethoxyphenyl)-5-(4-methoxyphenyl)-2-oxo-2,3-dihydrofuran-3,4-dicarboxylate (1432732-96-1)

Guidance literature:

With trifluoromethylsulfonic anhydride; In dichloromethane; at -10 ℃; for 2h; Solvent; Overall yield = 50 %; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2013.03.101

Reference yield:

dimethyl 2-(4-methoxyphenyl)furan-3,4-dicarboxylate (82577-49-9) → dimethyl 2-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-3,4-dicarboxylate (1432732-95-0) + dimethyl 3-(3,4-dimethoxyphenyl)-5-(4-methoxyphenyl)-2-oxo-2,3-dihydrofuran-3,4-dicarboxylate (1432732-96-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: oxygen / dichloromethane / -20 °C / Irradiation

1.2: 0.5 h / 20 °C

2.1: trifluoromethylsulfonic anhydride / dichloromethane / 2 h / -10 °C / Inert atmosphere

With trifluoromethylsulfonic anhydride; oxygen; In dichloromethane; 2.1: |Friedel-Crafts Acylation;

DOI:10.1016/j.tet.2013.03.101

upstream raw materials:

1,2-dimethoxybenzene

dimethyl 2-(4-methoxyphenyl)furan-3,4-dicarboxylate