(2R)-2-<(3-Hydroxyphenyl)acetamido>-N-(4-fluoro-3-nitrophenethyl)-p-methoxyphenylacetamide

Base Information

Chemical Name:(2R)-2-<(3-Hydroxyphenyl)acetamido>-N-(4-fluoro-3-nitrophenethyl)-p-methoxyphenylacetamide
CAS No.:157662-72-1
Molecular Formula:C₂₅H₂₄FN₃O₆
Molecular Weight:481.48
Hs Code.:

Synonyms:(2R)-2-<(3-Hydroxyphenyl)acetamido>-N-(4-fluoro-3-nitrophenethyl)-p-methoxyphenylacetamide

Suppliers and Price of (2R)-2-<(3-Hydroxyphenyl)acetamido>-N-(4-fluoro-3-nitrophenethyl)-p-methoxyphenylacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-2-<(3-Hydroxyphenyl)acetamido>-N-(4-fluoro-3-nitrophenethyl)-p-methoxyphenylacetamide

Chemical Property:

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Technology Process of (2R)-2-<(3-Hydroxyphenyl)acetamido>-N-(4-fluoro-3-nitrophenethyl)-p-methoxyphenylacetamide

There total 10 articles about (2R)-2-<(3-Hydroxyphenyl)acetamido>-N-(4-fluoro-3-nitrophenethyl)-p-methoxyphenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 157662-72-1
(2R)-2-<(3-Hydroxyphenyl)acetamido>-N-(4-fluoro-3-nitrophenethyl)-p-methoxyphenylacetamide

Guidance literature:: Multi-step reaction with 8 steps

1: 87 percent / NaBH₄ / diethyl ether

2: 82 percent / PBr₃ / toluene

3: 75 percent / acetonitrile

4: 62 percent / LiAlH₄, AlCl₃

5: DCC / tetrahydrofuran; CH₂Cl₂

6: K₂CO₃ / acetone

7: TFA

8: DCC

With sodium tetrahydroborate; lithium aluminium tetrahydride; aluminium trichloride; phosphorus tribromide; potassium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; acetone; toluene; acetonitrile;
DOI:10.1039/c39940000439

Reference yield:

: 621-37-4
m-hydroxyphenylacetic acid

: (R)-2-Amino-N-[2-(4-fluoro-3-nitro-phenyl)-ethyl]-2-(4-methoxy-phenyl)-acetamide; compound with trifluoro-acetic acid

: 157662-72-1
(2R)-2-<(3-Hydroxyphenyl)acetamido>-N-(4-fluoro-3-nitrophenethyl)-p-methoxyphenylacetamide

Guidance literature:: With N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; for 10h; Yield given;
DOI:10.1021/jo00098a010

Reference yield:

: 20274-69-5
(4-fluoro-3-nitrophenyl)methanol

: 157662-72-1
(2R)-2-<(3-Hydroxyphenyl)acetamido>-N-(4-fluoro-3-nitrophenethyl)-p-methoxyphenylacetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / PBr₃ / toluene

2: 75 percent / acetonitrile

3: 62 percent / LiAlH₄, AlCl₃

4: DCC / tetrahydrofuran; CH₂Cl₂

5: K₂CO₃ / acetone

6: TFA

7: DCC

With lithium aluminium tetrahydride; aluminium trichloride; phosphorus tribromide; potassium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetone; toluene; acetonitrile;
DOI:10.1039/c39940000439