3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 2,6-dichloro-4-nitrophenylamide

Base Information

Chemical Name:3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 2,6-dichloro-4-nitrophenylamide
CAS No.:1235471-29-0
Molecular Formula:C₁₇H₈Cl₂F₃N₃O₄
Molecular Weight:446.169
Hs Code.:

Synonyms:3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 2,6-dichloro-4-nitrophenylamide

Suppliers and Price of 3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 2,6-dichloro-4-nitrophenylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 2,6-dichloro-4-nitrophenylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 2,6-dichloro-4-nitrophenylamide

There total 7 articles about 3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 2,6-dichloro-4-nitrophenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: C₁₁H₅ClF₃NO₂

: 99-30-9
4-nitro-2,6-dichloroaniline

: 1235471-29-0
3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 2,6-dichloro-4-nitrophenylamide

Guidance literature:: 4-nitro-2,6-dichloroaniline; With tert.-butyl lithium; In diethyl ether; hexane; at -78 ℃;

C₁₁H₅ClF₃NO₂; In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; hexane; at -78 - 20 ℃;
DOI:10.1007/s00706-010-0265-9

Reference yield:

: 886967-65-3
ethyl 3-(4-trifluoromethylphenyl)-4,5-dihydroisoxazole-5-carboxylate

: 1235471-29-0
3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 2,6-dichloro-4-nitrophenylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide

2.1: water; sodium hydroxide / ethanol

3.1: oxalyl dichloride / benzene

4.1: tert.-butyl lithium / diethyl ether; hexane / -78 °C

4.2: -78 - 20 °C

With N-Bromosuccinimide; oxalyl dichloride; water; tert.-butyl lithium; sodium hydroxide; In diethyl ether; ethanol; hexane; benzene;
DOI:10.1007/s00706-010-0265-9

Reference yield:

: 66046-34-2
4-(trifluoromethyl)benzaldehyde oxime

: 1235471-29-0
3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 2,6-dichloro-4-nitrophenylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide

2.1: magnesium sulfate; triethylamine / toluene / 20 °C

3.1: N-Bromosuccinimide

4.1: water; sodium hydroxide / ethanol

5.1: oxalyl dichloride / benzene

6.1: tert.-butyl lithium / diethyl ether; hexane / -78 °C

6.2: -78 - 20 °C

With N-chloro-succinimide; N-Bromosuccinimide; oxalyl dichloride; water; tert.-butyl lithium; magnesium sulfate; triethylamine; sodium hydroxide; In diethyl ether; ethanol; hexane; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1007/s00706-010-0265-9