10-(4-(chloromethyl)phenyl)-5,5-difluoro-1,3,7,9-tetramethyl-5H-4l4,5l4-dipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinine

Base Information

• Chemical Name: 10-(4-(chloromethyl)phenyl)-5,5-difluoro-1,3,7,9-tetramethyl-5H-4l4,5l4-dipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinine
• CAS No.: 1397866-95-3
• Molecular Formula: C₂₀H₂₀BClF₂N₂
• Molecular Weight: 372.653
• Mol file: 1397866-95-3.mol

Synonyms:10-(4-(chloromethyl)phenyl)-5,5-difluoro-1,3,7,9-tetramethyl-5H-4l4,5l4-dipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinine

Chemical Property of 10-(4-(chloromethyl)phenyl)-5,5-difluoro-1,3,7,9-tetramethyl-5H-4l4,5l4-dipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-(4-(chloromethyl)phenyl)-5,5-difluoro-1,3,7,9-tetramethyl-5H-4l4,5l4-dipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinine

There total 2 articles about 10-(4-(chloromethyl)phenyl)-5,5-difluoro-1,3,7,9-tetramethyl-5H-4l4,5l4-dipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

2,4-dimethyl-1H-pyrrole (625-82-1) + p-(chloromethyl)benzoyl chloride (876-08-4) → 10-(4-(chloromethyl)phenyl)-5,5-difluoro-1,3,7,9-tetramethyl-5H-4l4,5l4-dipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinine (1397866-95-3)

Guidance literature:

2,4-dimethyl-1H-pyrrole; p-(chloromethyl)benzoyl chloride; In dichloromethane; at 30 ℃; for 4.5h; Inert atmosphere;

With boron trifluoride diethyl etherate; triethylamine; In dichloromethane; for 5.5h; Inert atmosphere;

DOI:10.1021/acs.bioconjchem.8b00600

Reference yield:

2,4-dimethyl-1H-pyrrole (625-82-1) + boron trifluoride diethyl etherate (109-63-7) + 4-chloromethylacetophenone (54589-56-9) → 10-(4-(chloromethyl)phenyl)-5,5-difluoro-1,3,7,9-tetramethyl-5H-4l4,5l4-dipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinine (1397866-95-3)

Guidance literature:

With triethylamine;

DOI:10.1039/c7dt03976j

Reference yield: 100.0%

10-(4-(chloromethyl)phenyl)-5,5-difluoro-1,3,7,9-tetramethyl-5H-4l4,5l4-dipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinine (1397866-95-3) → C20H20BF2N5

Guidance literature:

With sodium azide; potassium iodide; In N,N-dimethyl-formamide; at 45 ℃;

DOI:10.1002/chem.202002139

upstream raw materials:

2,4-dimethyl-1H-pyrrole

p-(chloromethyl)benzoyl chloride

boron trifluoride diethyl etherate

4-chloromethylacetophenone

Downstream raw materials:

C₂₂H₂₆BF₂N₃

C₂₀H₂₂BF₂N₃O