C₄₈H₈₆O₆Si₃

Base Information

Chemical Name:C₄₈H₈₆O₆Si₃
CAS No.:899798-82-4
Molecular Formula:C₄₈H₈₆O₆Si₃
Molecular Weight:843.464
Hs Code.:

C<sub>48</sub>H<sub>86</sub>O<sub>6</sub>Si<sub>3</sub>

Synonyms:C₄₈H₈₆O₆Si₃

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Chemical Property of C₄₈H₈₆O₆Si₃

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Technology Process of C₄₈H₈₆O₆Si₃

There total 20 articles about C₄₈H₈₆O₆Si₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 872369-17-0
(2R,3S)-5-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-2-methylpentanal

: 899798-82-4
C₄₈H₈₆O₆Si₃

Guidance literature:: Multi-step reaction with 11 steps

1.1: nBu₂BOTf; N,N-diisopropylethylamine / CH₂Cl₂ / 0.5 h / -5 °C

1.2: 3.98 g / CH₂Cl₂ / 16 h / -78 °C

2.1: 2,6-lutidine / CH₂Cl₂ / 1 h / Heating

3.1: lithium hydroxide monohydrate; hydrogen peroxide / tetrahydrofuran; H₂O / 36 h / 20 °C

4.1: 1,1'-carbonyldiimidazole / CH₂Cl₂ / 0.5 h / 0 °C

4.2: 2.07 g / CH₂Cl₂ / 16 h / 20 °C

5.1: 78 percent / tetrahydrofuran; diethyl ether / 1.25 h / -20 - 0 °C

6.1: 1.16 g / dimethylaluminum chloride; tributyltin hydride / CH₂Cl₂; hexane / 1 h / -90 °C

7.1: 85 percent / proton sponge(R) / CHCl₃ / 16 h / Heating

8.1: 98 percent / hydrogen / palladium hydroxide on carbon / ethanol / 3 h / 20 °C / atmospheric pressure

9.1: 91 percent / tributylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 1.5 h / 0 °C

10.1: 86 percent / hydrogen peroxide; Mo₇O₂₄(NH₄)6*4H₂O / ethanol; H₂O / 16 h / 20 °C

11.1: 75 percent Turnov_. / sodium hexamethyldisilazide / 1,2-dimethoxy-ethane; hexamethylphosphoric acid triamide; tetrahydrofuran / 2 h / -78 °C

With 2,6-dimethylpyridine; lithium hydroxide; ammonium molybdate tetrahydrate; tributylphosphine; di-isopropyl azodicarboxylate; di-n-butylboryl trifluoromethanesulfonate; hydrogen; dihydrogen peroxide; tri-n-butyl-tin hydride; sodium hexamethyldisilazane; dimethylaluminum chloride; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; palladium dihydroxide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; 1,2-dimethoxyethane; diethyl ether; ethanol; hexane; dichloromethane; chloroform; water; 9.1: Mitsunobu reaction / 11.1: Julia-Kocienski olefination;
DOI:10.1021/ol060669w

Reference yield:

: 899798-79-9
(2S,3R,4S,5R,6S)-8-Benzyloxy-4,6-bis-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethyl-octan-2-ol

: 899798-82-4
C₄₈H₈₆O₆Si₃

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / proton sponge(R) / CHCl₃ / 16 h / Heating

2: 98 percent / hydrogen / palladium hydroxide on carbon / ethanol / 3 h / 20 °C / atmospheric pressure

3: 91 percent / tributylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 1.5 h / 0 °C

4: 86 percent / hydrogen peroxide; Mo₇O₂₄(NH₄)6*4H₂O / ethanol; H₂O / 16 h / 20 °C

5: 75 percent Turnov_. / sodium hexamethyldisilazide / 1,2-dimethoxy-ethane; hexamethylphosphoric acid triamide; tetrahydrofuran / 2 h / -78 °C

With ammonium molybdate tetrahydrate; tributylphosphine; di-isopropyl azodicarboxylate; hydrogen; dihydrogen peroxide; sodium hexamethyldisilazane; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; palladium dihydroxide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; 1,2-dimethoxyethane; ethanol; chloroform; water; 3: Mitsunobu reaction / 5: Julia-Kocienski olefination;
DOI:10.1021/ol060669w

Reference yield:

: 899798-76-6
(2S,3R,4R,5S)-7-Benzyloxy-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-heptanoic acid

: 899798-82-4
C₄₈H₈₆O₆Si₃

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1,1'-carbonyldiimidazole / CH₂Cl₂ / 0.5 h / 0 °C

1.2: 2.07 g / CH₂Cl₂ / 16 h / 20 °C

2.1: 78 percent / tetrahydrofuran; diethyl ether / 1.25 h / -20 - 0 °C

3.1: 1.16 g / dimethylaluminum chloride; tributyltin hydride / CH₂Cl₂; hexane / 1 h / -90 °C

4.1: 85 percent / proton sponge(R) / CHCl₃ / 16 h / Heating

5.1: 98 percent / hydrogen / palladium hydroxide on carbon / ethanol / 3 h / 20 °C / atmospheric pressure

6.1: 91 percent / tributylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 1.5 h / 0 °C

7.1: 86 percent / hydrogen peroxide; Mo₇O₂₄(NH₄)6*4H₂O / ethanol; H₂O / 16 h / 20 °C

8.1: 75 percent Turnov_. / sodium hexamethyldisilazide / 1,2-dimethoxy-ethane; hexamethylphosphoric acid triamide; tetrahydrofuran / 2 h / -78 °C

With ammonium molybdate tetrahydrate; tributylphosphine; di-isopropyl azodicarboxylate; hydrogen; dihydrogen peroxide; tri-n-butyl-tin hydride; sodium hexamethyldisilazane; dimethylaluminum chloride; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; 1,1'-carbonyldiimidazole; palladium dihydroxide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; 1,2-dimethoxyethane; diethyl ether; ethanol; hexane; dichloromethane; chloroform; water; 6.1: Mitsunobu reaction / 8.1: Julia-Kocienski olefination;
DOI:10.1021/ol060669w