Technology Process of 6-hydroxy-8-phenyl-5-quinoxalinecarboxylic acid
There total 6 articles about 6-hydroxy-8-phenyl-5-quinoxalinecarboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 3-amino-5-(methyloxy)-2-nitro-4-biphenylcarboxylate;
With
hydrogen;
palladium 10% on activated carbon;
In
ethyl acetate;
at 20 ℃;
for 24h;
under 760.051 Torr;
Glyoxal;
In
water; acetonitrile;
at 120 ℃;
for 0.333333h;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sulfuric acid; nitric acid / 0 - 20 °C
2.1: ammonium hydroxide / methanol; water / 20 °C
3.1: sodium methylate / methanol / 0 - 20 °C
4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 0.5 h / 120 °C / Microwave irradiation
5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 24 h / 20 °C / 760.05 Torr
5.2: 0.33 h / 120 °C / Microwave irradiation
With
ammonium hydroxide; sulfuric acid; hydrogen; nitric acid; sodium methylate; potassium carbonate;
tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
1,4-dioxane; methanol; water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: ammonium hydroxide / methanol; water / 20 °C
2.1: sodium methylate / methanol / 0 - 20 °C
3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 0.5 h / 120 °C / Microwave irradiation
4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 24 h / 20 °C / 760.05 Torr
4.2: 0.33 h / 120 °C / Microwave irradiation
With
ammonium hydroxide; hydrogen; sodium methylate; potassium carbonate;
tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
1,4-dioxane; methanol; water; ethyl acetate;
