Methyl 4-bromo-2,6-difluorobenzoate

Base Information

• Chemical Name: Methyl 4-bromo-2,6-difluorobenzoate
• CAS No.: 773134-11-5
• Molecular Formula: C8H5BrF2O2
• Molecular Weight: 251.027
• Hs Code.: 2916399090
• Mol file: 773134-11-5.mol

Synonyms:Methyl4-bromo-2,6-difluorobenzoate;

Chemical Property of Methyl 4-bromo-2,6-difluorobenzoate

Chemical Property:

• Melting Point: 41-43℃
• Boiling Point: 276.1 °C at 760 mmHg
• Flash Point: 120.8 °C
• PSA: 26.30000
• Density: 1.652 g/cm³
• LogP: 2.51390
• Storage Temp.: Room temperature.

Purity/Quality:

97% ^*data from raw suppliers

Methyl4-bromo-2,6-difluorobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4-bromo-2,6-difluorobenzoate

There total 9 articles about Methyl 4-bromo-2,6-difluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-bromo-2,6-difluorobenzoic acid (183065-68-1) + diazomethyl-trimethyl-silane (18107-18-1) → 4-bromo-2,6-difluorobenzoic acid methyl ester (773134-11-5)

Guidance literature:

In methanol; diethyl ether; dichloromethane; at 20 ℃;

Reference yield: 92.0%

methanol (67-56-1) + 4-bromo-2,6-difluorobenzoic acid (183065-68-1) → 4-bromo-2,6-difluorobenzoic acid methyl ester (773134-11-5)

Guidance literature:

With sulfuric acid; for 14h; Reflux;

DOI:10.1021/acs.inorgchem.8b00404

Reference yield: 90.0%

4-bromo-2,6-difluorobenzoic acid (183065-68-1) → 4-bromo-2,6-difluorobenzoic acid methyl ester (773134-11-5)

Guidance literature:

With thionyl chloride; In methanol; for 3h; Reflux;

upstream raw materials:

methanol

2,6-difluoro-4-bromobenzoyl chloride

4-bromo-2,6-difluorobenzoic acid

methyl iodide

Downstream raw materials:

methyl 4-bromo-2-fluoro-6-nitromethylbenzoate

methyl 4-(2-cyclopropylethynyl)-2,6-difluorobenzoate

Methyl 2,6-difluoro-4-(3,3-dimethylbut-1-ynyl)benzoate

methyl 4-bromo-2-fluoro-6-hydroxybenzoate