2-(3-hydroxymethyl-4-hydroxyphenyl)ethylacetate

Base Information

• Chemical Name: 2-(3-hydroxymethyl-4-hydroxyphenyl)ethylacetate
• CAS No.: 722539-67-5
• Molecular Formula: C₁₁H₁₄O₄
• Molecular Weight: 210.23
• Mol file: 722539-67-5.mol

Synonyms:2-(3-hydroxymethyl-4-hydroxyphenyl)ethylacetate

Chemical Property of 2-(3-hydroxymethyl-4-hydroxyphenyl)ethylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-(3-hydroxymethyl-4-hydroxyphenyl)ethylacetate

There total 2 articles about 2-(3-hydroxymethyl-4-hydroxyphenyl)ethylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-(4-hydroxyphenyl)ethyl acetate (58556-55-1) → 2-(3-hydroxymethyl-4-hydroxyphenyl)ethylacetate (722539-67-5)

Guidance literature:

formaldehyd; 2-(4-hydroxyphenyl)ethyl acetate; With propionic acid; phenylboronic acid; In toluene; Heating;

With dihydrogen peroxide; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1081/NCN-120027820

Reference yield:

p-hydroxyphenethyl alcohol (501-94-0) → 2-(3-hydroxymethyl-4-hydroxyphenyl)ethylacetate (722539-67-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 87 percent / NaHSO₄*SiO₂ / hexane / 18 h / 67 °C

2.1: phenylboronic acid; propionic acid / toluene / Heating

2.2: 95 percent / aq. H₂O₂ / tetrahydrofuran / 0.5 h / 0 °C

With sodium hydrogen sulfate; silica gel; propionic acid; phenylboronic acid; In hexane; toluene;

DOI:10.1081/NCN-120027820

upstream raw materials:

formaldehyd

2-(4-hydroxyphenyl)ethyl acetate

p-hydroxyphenethyl alcohol

Refernces