tert-butyl (5-(4-(4-(dimethylcarbamoyl)phenoxy)-6-morpholino-1,3,5-triazin-2-yl)thiazol-2-yl)carbamate

Base Information

Chemical Name:tert-butyl (5-(4-(4-(dimethylcarbamoyl)phenoxy)-6-morpholino-1,3,5-triazin-2-yl)thiazol-2-yl)carbamate
CAS No.:1391926-40-1
Molecular Formula:C₂₄H₂₉N₇O₅S
Molecular Weight:527.604
Hs Code.:

Synonyms:tert-butyl (5-(4-(4-(dimethylcarbamoyl)phenoxy)-6-morpholino-1,3,5-triazin-2-yl)thiazol-2-yl)carbamate

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Chemical Property of tert-butyl (5-(4-(4-(dimethylcarbamoyl)phenoxy)-6-morpholino-1,3,5-triazin-2-yl)thiazol-2-yl)carbamate

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Technology Process of tert-butyl (5-(4-(4-(dimethylcarbamoyl)phenoxy)-6-morpholino-1,3,5-triazin-2-yl)thiazol-2-yl)carbamate

There total 9 articles about tert-butyl (5-(4-(4-(dimethylcarbamoyl)phenoxy)-6-morpholino-1,3,5-triazin-2-yl)thiazol-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1391926-57-0
C₁₆H₁₈ClN₅O₃

: 243972-26-1
tert-butyl (5-(tributylstannyl)thiazol-2-yl)carbamate

: 1391926-40-1
tert-butyl (5-(4-(4-(dimethylcarbamoyl)phenoxy)-6-morpholino-1,3,5-triazin-2-yl)thiazol-2-yl)carbamate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; for 4h; Reflux; Inert atmosphere;
DOI:10.1021/acs.jmedchem.0c01061

Reference yield:

: 170961-15-6
tert-butyl 1,3-thiazole-2-yl-carbamate

: 1391926-40-1
tert-butyl (5-(4-(4-(dimethylcarbamoyl)phenoxy)-6-morpholino-1,3,5-triazin-2-yl)thiazol-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium diisopropyl amide / tetrahydrofuran / -78 °C

2: bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 95 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 99-96-7
4-hydroxy-benzoic acid

: 1391926-40-1
tert-butyl (5-(4-(4-(dimethylcarbamoyl)phenoxy)-6-morpholino-1,3,5-triazin-2-yl)thiazol-2-yl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / 4 h / 20 °C

2: oxalyl dichloride / 4 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 20 °C

4: potassium carbonate / methanol / 5 h / 20 °C

5: sodium hydrogencarbonate / water; acetone / 2 h / 20 °C

6: bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 95 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; oxalyl dichloride; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone;