4-(2-benzyl-3-oxo-2,3,4,5-tetrahydrobenz[f][1,4]oxazepin-4-yl)benzonitrile

Base Information

Chemical Name:4-(2-benzyl-3-oxo-2,3,4,5-tetrahydrobenz[f][1,4]oxazepin-4-yl)benzonitrile
CAS No.:716317-02-1
Molecular Formula:C₂₃H₁₈N₂O₂
Molecular Weight:354.408
Hs Code.:

Synonyms:4-(2-benzyl-3-oxo-2,3,4,5-tetrahydrobenz[f][1,4]oxazepin-4-yl)benzonitrile

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Chemical Property of 4-(2-benzyl-3-oxo-2,3,4,5-tetrahydrobenz[f][1,4]oxazepin-4-yl)benzonitrile

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Technology Process of 4-(2-benzyl-3-oxo-2,3,4,5-tetrahydrobenz[f][1,4]oxazepin-4-yl)benzonitrile

There total 9 articles about 4-(2-benzyl-3-oxo-2,3,4,5-tetrahydrobenz[f][1,4]oxazepin-4-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 143-33-9,25596-52-5
sodium cyanide

: 716317-01-0
2-benzyl-4-(4-iodophenyl)-2,3,4,5-tetrahydrobenz[f][1,4]oxazepin-3-one

: 716317-02-1
4-(2-benzyl-3-oxo-2,3,4,5-tetrahydrobenz[f][1,4]oxazepin-4-yl)benzonitrile

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In acetonitrile; for 3.5h; Heating;
DOI:10.3987/com-04-10022

Reference yield: 73.0%

: 716316-98-2
2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-(4-cyanophenyl)-3-phenylpropionamide

: 716317-02-1
4-(2-benzyl-3-oxo-2,3,4,5-tetrahydrobenz[f][1,4]oxazepin-4-yl)benzonitrile

Guidance literature:: With tetrabutyl ammonium fluoride; In dichloromethane; at 0 ℃; for 3.5h;
DOI:10.3987/com-04-10022

Reference yield:

: 89-95-2
2-methyl-benzyl alcohol

: 716317-02-1
4-(2-benzyl-3-oxo-2,3,4,5-tetrahydrobenz[f][1,4]oxazepin-4-yl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: sodium borohydride / ethanol

2: 43 percent / triethylamine / CH₂Cl₂

3: 73 percent / potassium carbonate / acetone / Heating

4: 76 percent / copper(I) iodide / tetrakis(triphenylphosphine)palladium / acetonitrile / 3.5 h / Heating

With sodium tetrahydroborate; copper(l) iodide; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; acetone; acetonitrile;
DOI:10.3987/com-04-10022