Technology Process of 4-(tert-butyl-diphenyl-silanyloxymethyl)-hexanoic acid methyl ester
There total 13 articles about 4-(tert-butyl-diphenyl-silanyloxymethyl)-hexanoic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal; trifluoroacetic acid;
In
ethanol;
for 12h;
under 760.051 Torr;
DOI:10.1021/jo001767c
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: n-BuLi / tetrahydrofuran; various solvent(s) / 1 h / -78 °C
1.2: 100 percent / tetrahydrofuran; various solvent(s) / 1 h / -30 °C
2.1: 48 percent / Lipase PS3O / pentane / 24 h / 20 °C
3.1: 90 percent / K2CO3 / methanol / 13 h / 20 °C
4.1: DMSO; oxalyl chloride; Et3N / CH2Cl2 / -78 - 20 °C
5.1: LiN(Me3Si)2 / tetrahydrofuran / 0.33 h / -10 - 20 °C
5.2: 7.63 g / tetrahydrofuran / 0.5 h / 0 °C
6.1: 83 percent / aq. HF / acetonitrile; CH2Cl2 / 2 h / 20 °C
7.1: 85 percent / imidazole / dimethylformamide / 14 h / -5 - 20 °C
8.1: H2 / Pd/C; TFA / ethanol / 12 h / 760.05 Torr
With
1H-imidazole; n-butyllithium; oxalyl dichloride; Lipase PS3O; hydrogen fluoride; hydrogen; potassium carbonate; dimethyl sulfoxide; triethylamine; lithium hexamethyldisilazane;
palladium on activated charcoal; trifluoroacetic acid;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; pentane;
DOI:10.1021/jo001767c
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 48 percent / Lipase PS3O / pentane / 24 h / 20 °C
2.1: 90 percent / K2CO3 / methanol / 13 h / 20 °C
3.1: DMSO; oxalyl chloride; Et3N / CH2Cl2 / -78 - 20 °C
4.1: LiN(Me3Si)2 / tetrahydrofuran / 0.33 h / -10 - 20 °C
4.2: 7.63 g / tetrahydrofuran / 0.5 h / 0 °C
5.1: 83 percent / aq. HF / acetonitrile; CH2Cl2 / 2 h / 20 °C
6.1: 85 percent / imidazole / dimethylformamide / 14 h / -5 - 20 °C
7.1: H2 / Pd/C; TFA / ethanol / 12 h / 760.05 Torr
With
1H-imidazole; oxalyl dichloride; Lipase PS3O; hydrogen fluoride; hydrogen; potassium carbonate; dimethyl sulfoxide; triethylamine; lithium hexamethyldisilazane;
palladium on activated charcoal; trifluoroacetic acid;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; pentane;
DOI:10.1021/jo001767c
