t-butyl {3-[(6-chloropyridine-3-carbonyl)amino][1,1'-biphenyl]-4-yl}carbamate

Base Information

Chemical Name:t-butyl {3-[(6-chloropyridine-3-carbonyl)amino][1,1'-biphenyl]-4-yl}carbamate
CAS No.:937728-81-9
Molecular Formula:C₂₃H₂₂ClN₃O₃
Molecular Weight:423.899
Hs Code.:

Synonyms:t-butyl {3-[(6-chloropyridine-3-carbonyl)amino][1,1'-biphenyl]-4-yl}carbamate

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Chemical Property of t-butyl {3-[(6-chloropyridine-3-carbonyl)amino][1,1'-biphenyl]-4-yl}carbamate

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Technology Process of t-butyl {3-[(6-chloropyridine-3-carbonyl)amino][1,1'-biphenyl]-4-yl}carbamate

There total 6 articles about t-butyl {3-[(6-chloropyridine-3-carbonyl)amino][1,1'-biphenyl]-4-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 58757-38-3
6-Chloronicotinoyl chloride

: 335255-33-9
tert-butyl (3-amino-4-biphenylyl)carbamate

: 937728-81-9
t-butyl {3-[(6-chloropyridine-3-carbonyl)amino][1,1'-biphenyl]-4-yl}carbamate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 8h;
DOI:10.1021/acsmedchemlett.8b00099

Reference yield:

: 327046-79-7
tert-butyl (4-bromo-2-nitrophenyl)carbamate

: 937728-81-9
t-butyl {3-[(6-chloropyridine-3-carbonyl)amino][1,1'-biphenyl]-4-yl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / 1,4-dioxane; water / 0.5 h / Inert atmosphere

1.2: 20 h / 90 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / Inert atmosphere

3.1: pyridine / 1.5 h

With pyridine; palladium 10% on activated carbon; hydrogen; potassium carbonate; In 1,4-dioxane; water; ethyl acetate;
DOI:10.1021/ml4004233

Reference yield:

: 335254-77-8
tert-butyl (3-nitro-[1, 1'-biphenyl]-4-yl)carbamate

: 937728-81-9
t-butyl {3-[(6-chloropyridine-3-carbonyl)amino][1,1'-biphenyl]-4-yl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / Inert atmosphere

2: pyridine / 1.5 h

With pyridine; palladium 10% on activated carbon; hydrogen; In ethyl acetate;
DOI:10.1021/ml4004233