N-(5-(2-(5-(2-nitrobenzylidene)-4-oxo-3-phenylthiazolidin-2-ylidene)hydrazinecarbonyl)-4-methylthiazol-2-yl)-4-fluorobenzamide

Base Information

Chemical Name:N-(5-(2-(5-(2-nitrobenzylidene)-4-oxo-3-phenylthiazolidin-2-ylidene)hydrazinecarbonyl)-4-methylthiazol-2-yl)-4-fluorobenzamide
CAS No.:1418192-18-3
Molecular Formula:C₂₈H₁₉FN₆O₅S₂
Molecular Weight:602.626
Hs Code.:

Synonyms:N-(5-(2-(5-(2-nitrobenzylidene)-4-oxo-3-phenylthiazolidin-2-ylidene)hydrazinecarbonyl)-4-methylthiazol-2-yl)-4-fluorobenzamide

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Chemical Property of N-(5-(2-(5-(2-nitrobenzylidene)-4-oxo-3-phenylthiazolidin-2-ylidene)hydrazinecarbonyl)-4-methylthiazol-2-yl)-4-fluorobenzamide

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Technology Process of N-(5-(2-(5-(2-nitrobenzylidene)-4-oxo-3-phenylthiazolidin-2-ylidene)hydrazinecarbonyl)-4-methylthiazol-2-yl)-4-fluorobenzamide

There total 5 articles about N-(5-(2-(5-(2-nitrobenzylidene)-4-oxo-3-phenylthiazolidin-2-ylidene)hydrazinecarbonyl)-4-methylthiazol-2-yl)-4-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1418192-05-8
4-fluoro-N-(4-methyl-5-(2-(4-oxo-3-phenylthiazolidin-2-ylidene)hydrazinecarbonyl)thiazol-2-yl)benzamide

: 552-89-6
2-nitro-benzaldehyde

: 1418192-18-3
N-(5-(2-(5-(2-nitrobenzylidene)-4-oxo-3-phenylthiazolidin-2-ylidene)hydrazinecarbonyl)-4-methylthiazol-2-yl)-4-fluorobenzamide

Guidance literature:: With silica gel; In N,N-dimethyl-formamide; for 0.0666667h; Inert atmosphere; Microwave irradiation; Green chemistry;
DOI:10.1016/j.jfluchem.2012.10.012

Reference yield:

: 7210-76-6
ethyl-2-amino-4-methylthiazole-5-carboxylate

: 1418192-18-3
N-(5-(2-(5-(2-nitrobenzylidene)-4-oxo-3-phenylthiazolidin-2-ylidene)hydrazinecarbonyl)-4-methylthiazol-2-yl)-4-fluorobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / 0.03 h / Microwave irradiation; Inert atmosphere; Green chemistry

2: hydrazine hydrate / N,N-dimethyl-formamide / 0.02 h / Microwave irradiation; Inert atmosphere; Green chemistry

3: acetic acid / 0.07 h / Microwave irradiation; Inert atmosphere; Green chemistry

4: sodium acetate / tetrahydrofuran / 0.08 h / Microwave irradiation; Inert atmosphere; Green chemistry

5: silica gel / N,N-dimethyl-formamide / 0.07 h / Inert atmosphere; Microwave irradiation; Green chemistry

With sodium acetate; silica gel; hydrazine hydrate; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide; 5: |Knoevenagel Condensation;
DOI:10.1016/j.jfluchem.2012.10.012

Reference yield:

: 403-43-0
4-fluorobenzoyl chloride

: 1418192-18-3
N-(5-(2-(5-(2-nitrobenzylidene)-4-oxo-3-phenylthiazolidin-2-ylidene)hydrazinecarbonyl)-4-methylthiazol-2-yl)-4-fluorobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / 0.03 h / Microwave irradiation; Inert atmosphere; Green chemistry

2: hydrazine hydrate / N,N-dimethyl-formamide / 0.02 h / Microwave irradiation; Inert atmosphere; Green chemistry

3: acetic acid / 0.07 h / Microwave irradiation; Inert atmosphere; Green chemistry

4: sodium acetate / tetrahydrofuran / 0.08 h / Microwave irradiation; Inert atmosphere; Green chemistry

5: silica gel / N,N-dimethyl-formamide / 0.07 h / Inert atmosphere; Microwave irradiation; Green chemistry

With sodium acetate; silica gel; hydrazine hydrate; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide; 5: |Knoevenagel Condensation;
DOI:10.1016/j.jfluchem.2012.10.012