4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-fluorobenzoic acid

Base Information

Chemical Name:4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-fluorobenzoic acid
CAS No.:1288339-46-7
Molecular Formula:C₁₄H₁₀F₄N₂O₂
Molecular Weight:314.239
Hs Code.:

Synonyms:4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-fluorobenzoic acid

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Chemical Property of 4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-fluorobenzoic acid

Chemical Property:

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Technology Process of 4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-fluorobenzoic acid

There total 3 articles about 4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-38-9,18923-20-1
carbon dioxide

: 1288339-45-6
5-cyclopropyl-1-(2-fluoro-4-iodophenyl)-3-(trifluoromethyl)-1H-pyrazole

: 74-88-4
methyl iodide

: 1288339-46-7
4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-fluorobenzoic acid

Guidance literature:: methyl iodide; With iodine; magnesium; Inert atmosphere; Reflux;

5-cyclopropyl-1-(2-fluoro-4-iodophenyl)-3-(trifluoromethyl)-1H-pyrazole; Reflux;

carbon dioxide; With hydrogenchloride; water; at 25 - 28 ℃;

Reference yield:

: 1318763-41-5
5-cyclopropyl-1-(2-fluoro-4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole

: 1288339-46-7
4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium chloride; iron / ethanol; water / 1 h / Reflux

2.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 °C

2.2: 0 - 28 °C

3.1: iodine; magnesium / Inert atmosphere; Reflux

3.2: Reflux

3.3: 25 - 28 °C

With hydrogenchloride; iodine; iron; ammonium chloride; magnesium; sodium nitrite; In ethanol; water; 3.1: Grignard Reaction;

Reference yield:

: 1288339-40-1
4-[3-cyclopropyl-5-(trifluoromethyl)-1H-pyrazol-1-yl]-3-fluoroaniline

: 1288339-46-7
4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 °C

1.2: 0 - 28 °C

2.1: iodine; magnesium / Inert atmosphere; Reflux

2.2: Reflux

2.3: 25 - 28 °C

With hydrogenchloride; iodine; magnesium; sodium nitrite; In water; 2.1: Grignard Reaction;