N-<4-<1-hydroxy-2-(1H-imidazol-1-yl)-1-methylethyl>phenyl>-N-(phenylmethyl)methanesulfonamide

Base Information

Chemical Name:N-<4-<1-hydroxy-2-(1H-imidazol-1-yl)-1-methylethyl>phenyl>-N-(phenylmethyl)methanesulfonamide
CAS No.:110698-63-0
Molecular Formula:C₂₀H₂₃N₃O₃S
Molecular Weight:385.487
Hs Code.:

Synonyms:N-<4-<1-hydroxy-2-(1H-imidazol-1-yl)-1-methylethyl>phenyl>-N-(phenylmethyl)methanesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<4-<1-hydroxy-2-(1H-imidazol-1-yl)-1-methylethyl>phenyl>-N-(phenylmethyl)methanesulfonamide

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Technology Process of N-<4-<1-hydroxy-2-(1H-imidazol-1-yl)-1-methylethyl>phenyl>-N-(phenylmethyl)methanesulfonamide

There total 4 articles about N-<4-<1-hydroxy-2-(1H-imidazol-1-yl)-1-methylethyl>phenyl>-N-(phenylmethyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 75-16-1
methylmagnesium bromide

: 110698-71-0
N-<4-<2-(1H-imidazol-1-yl)-1-oxoethyl>phenyl>-N-(phenylmethyl)methanesulfonamide

: 110698-63-0
N-<4-<1-hydroxy-2-(1H-imidazol-1-yl)-1-methylethyl>phenyl>-N-(phenylmethyl)methanesulfonamide

Guidance literature:: In tetrahydrofuran; diethyl ether; 1.) 0 deg C, 30 min, 2.) RT, 18 h;
DOI:10.1021/jm00395a021

Reference yield:

: 100-39-0
benzyl bromide

: 110698-63-0
N-<4-<1-hydroxy-2-(1H-imidazol-1-yl)-1-methylethyl>phenyl>-N-(phenylmethyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) sodium methoxide / 1.) methanol, RT, 30 min, 2.) methanol, RT, 28 h

2: 90.0 g / bromine / acetic acid / 17 h / Ambient temperature

3: 68 percent / acetonitrile / 1.) 0 deg C, 2 h, 2.) RT, 15 h

4: 77 percent / tetrahydrofuran; diethyl ether / 1.) 0 deg C, 30 min, 2.) RT, 18 h

With bromine; sodium methylate; In tetrahydrofuran; diethyl ether; acetic acid; acetonitrile;
DOI:10.1021/jm00395a021

Reference yield:

: 110698-70-9
N-<4-(1-oxoethyl)phenyl>-N-(phenylmethyl)methanesulfonamide

: 110698-63-0
N-<4-<1-hydroxy-2-(1H-imidazol-1-yl)-1-methylethyl>phenyl>-N-(phenylmethyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 90.0 g / bromine / acetic acid / 17 h / Ambient temperature

2: 68 percent / acetonitrile / 1.) 0 deg C, 2 h, 2.) RT, 15 h

3: 77 percent / tetrahydrofuran; diethyl ether / 1.) 0 deg C, 30 min, 2.) RT, 18 h

With bromine; In tetrahydrofuran; diethyl ether; acetic acid; acetonitrile;
DOI:10.1021/jm00395a021