7-ethoxy-6-methyl-1-(phenylsulfonyl)-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole

Base Information

Chemical Name:7-ethoxy-6-methyl-1-(phenylsulfonyl)-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole
CAS No.:1059129-34-8
Molecular Formula:C₂₀H₂₂N₂O₃S
Molecular Weight:370.472
Hs Code.:

Synonyms:7-ethoxy-6-methyl-1-(phenylsulfonyl)-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole

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Chemical Property of 7-ethoxy-6-methyl-1-(phenylsulfonyl)-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole

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Technology Process of 7-ethoxy-6-methyl-1-(phenylsulfonyl)-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole

There total 5 articles about 7-ethoxy-6-methyl-1-(phenylsulfonyl)-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1059131-22-4
tert-butyl 7-hydroxy-6-methyl-1-(phenylsulfonyl)-1,3,4,6-tetrahydro-5H-azepino[5,4,3-cd]indole-5-carboxylate

: 75-03-6
ethyl iodide

: 1059129-34-8
7-ethoxy-6-methyl-1-(phenylsulfonyl)-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole

Guidance literature:: tert-butyl 7-hydroxy-6-methyl-1-(phenylsulfonyl)-1,3,4,6-tetrahydro-5H-azepino[5,4,3-cd]indole-5-carboxylate; ethyl iodide; With potassium carbonate; In acetone; at 62 ℃;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With water; ammonium bicarbonate; In acetonitrile; pH=10;

Reference yield:

: 1059131-20-2
tert-butyl 7-(acetyloxy)-6-methyl-1,3,4,6-tetrahydro-5H-azepino[5,4,3-cd]indole-5-carboxylate

: 1059129-34-8
7-ethoxy-6-methyl-1-(phenylsulfonyl)-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.05 h / 0 °C

1.2: 20 °C

2.1: potassium carbonate / acetone / 62 °C

2.2: 2 h / 20 °C

2.3: pH 10

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; acetone;

Reference yield:

: 1059131-21-3
C₁₇H₂₂N₂O₃

: 1059129-34-8
7-ethoxy-6-methyl-1-(phenylsulfonyl)-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.05 h / 0 °C

2.2: 20 °C

3.1: potassium carbonate / acetone / 62 °C

3.2: 2 h / 20 °C

3.3: pH 10

With pyridine; sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; acetone;