N-1-[3-(1H-indol-3-yl)propyl]-4-methyl-1-benzenesulfonamide

Base Information

• Chemical Name: N-1-[3-(1H-indol-3-yl)propyl]-4-methyl-1-benzenesulfonamide
• CAS No.: 1158201-42-3
• Molecular Formula: C₁₈H₂₀N₂O₂S
• Molecular Weight: 328.435
• Mol file: 1158201-42-3.mol

Synonyms:N-1-[3-(1H-indol-3-yl)propyl]-4-methyl-1-benzenesulfonamide

Chemical Property of N-1-[3-(1H-indol-3-yl)propyl]-4-methyl-1-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-1-[3-(1H-indol-3-yl)propyl]-4-methyl-1-benzenesulfonamide

There total 8 articles about N-1-[3-(1H-indol-3-yl)propyl]-4-methyl-1-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

Homotryptamine (6245-89-2) + p-toluenesulfonyl chloride (98-59-9) → N-1-[3-(1H-indol-3-yl)propyl]-4-methyl-1-benzenesulfonamide (1158201-42-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c03001

Reference yield: 80.0%

indole (120-72-9) + 1-(toluene-4-sulfonyl)azetidine (7730-45-2) → N-1-[3-(1H-indol-3-yl)propyl]-4-methyl-1-benzenesulfonamide (1158201-42-3)

Guidance literature:

With indium(III) bromide; In 1,1-dichloroethane; for 4.5h; Reflux;

DOI:10.1055/s-0028-1087957

Reference yield:

toluene-4-sulfonic acid 3-(1H-indol-3-yl)propyl ester (25109-08-4) + toluene-4-sulfonamide (70-55-3) → N-1-[3-(1H-indol-3-yl)propyl]-4-methyl-1-benzenesulfonamide (1158201-42-3)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; at 120 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b03155

upstream raw materials:

indole

1-(toluene-4-sulfonyl)azetidine

Homotryptamine

p-toluenesulfonyl chloride