(2S,5S)-(-)-1-(3,5-dimethylphenyl)-1-oxo-2,5-diphenylphospholane

Base Information

• Chemical Name: (2S,5S)-(-)-1-(3,5-dimethylphenyl)-1-oxo-2,5-diphenylphospholane
• CAS No.: 882353-88-0
• Molecular Formula: C₂₄H₂₅OP
• Molecular Weight: 360.436
• Mol file: 882353-88-0.mol

Synonyms:(2S,5S)-(-)-1-(3,5-dimethylphenyl)-1-oxo-2,5-diphenylphospholane

Chemical Property of (2S,5S)-(-)-1-(3,5-dimethylphenyl)-1-oxo-2,5-diphenylphospholane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,5S)-(-)-1-(3,5-dimethylphenyl)-1-oxo-2,5-diphenylphospholane

There total 6 articles about (2S,5S)-(-)-1-(3,5-dimethylphenyl)-1-oxo-2,5-diphenylphospholane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

5-bromo-1,3-xylene (556-96-7) + (S,S)-(-)-1-chloro-1-r-oxo-2-c,5-t-diphenylphospholane (474093-56-6) → (2S,5S)-(-)-1-(3,5-dimethylphenyl)-1-oxo-2,5-diphenylphospholane (882353-88-0)

Guidance literature:

5-bromo-1,3-xylene; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃;

With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; at -40 - 20 ℃; for 0.25h;

(S,S)-(-)-1-chloro-1-r-oxo-2-c,5-t-diphenylphospholane; In tetrahydrofuran; at -60 - 20 ℃;

DOI:10.1002/ejoc.200500577

Reference yield: 54.0%

trifluoromethanesulfonic acid 3,5-dimethylphenyl ester (219667-41-1) + (S,S)-(-)-1-r-oxo-2-c,5-t-diphenylphospholane (474093-57-7) → (2S,5S)-(-)-1-(3,5-dimethylphenyl)-1-oxo-2,5-diphenylphospholane (882353-88-0)

Guidance literature:

With 1,3-bis-(diphenylphosphino)propane; N-isopropylethylamine; palladium diacetate; In dimethyl sulfoxide; at 100 ℃; for 24h;

DOI:10.1002/ejoc.200500577

Reference yield: 50.0%

(2S,5S)-2,5-diphenyl-1-(3,5-dimethylphenyl)phospholane (949093-98-5) → (2S,5S)-(-)-1-(3,5-dimethylphenyl)-1-oxo-2,5-diphenylphospholane (882353-88-0)

Guidance literature:

With dihydrogen peroxide; In Petroleum ether; at -15 ℃; for 4h;

DOI:10.1016/j.tet.2007.05.053

upstream raw materials:

5-bromo-1,3-xylene

(S,S)-(-)-1-chloro-1-r-oxo-2-c,5-t-diphenylphospholane

trifluoromethanesulfonic acid 3,5-dimethylphenyl ester

(S,S)-(-)-1-r-oxo-2-c,5-t-diphenylphospholane