(S)-1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl 2-aminopropanoate

Base Information

Chemical Name:(S)-1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl 2-aminopropanoate
CAS No.:1285548-16-4
Molecular Formula:C₂₆H₄₁ClN₄O₅
Molecular Weight:525.088
Hs Code.:

Synonyms:(S)-1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl 2-aminopropanoate

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Chemical Property of (S)-1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl 2-aminopropanoate

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Technology Process of (S)-1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl 2-aminopropanoate

There total 11 articles about (S)-1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl 2-aminopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.4%

: 1285548-76-6
(S)-1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl 2-(tert-butoxycarbonylamino)propanoate

: 1285548-16-4
(S)-1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl 2-aminopropanoate

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃;

Reference yield:

: 475085-56-4
4-(4-chloro-phenyl)-4-hydroxy-3,3-dimethyl-piperidine-1-carboxylic acid tert-butyl ester

: 1285548-16-4
(S)-1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl 2-aminopropanoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

2.1: butanone; water / 20 °C / Reflux

3.1: sodium hydroxide / water

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C

4.2: 20 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 2.5 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

6.2: 1 h

7.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere; Reflux

8.1: dicyclohexyl-carbodiimide / dmap / dichloromethane / 24 h / 20 °C

9.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 20 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; sodium hydroxide; dmap; benzotriazol-1-ol; In 1,4-dioxane; dichloromethane; water; acetonitrile; butanone;

Reference yield:

: 690660-21-0
4-(4-chloro-phenyl)-3,3-dimethyl-piperidin-4-ol

: 1285548-16-4
(S)-1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl 2-aminopropanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: butanone; water / 20 °C / Reflux

2.1: sodium hydroxide / water

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C

3.2: 20 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 2.5 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

5.2: 1 h

6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere; Reflux

7.1: dicyclohexyl-carbodiimide / dmap / dichloromethane / 24 h / 20 °C

8.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 20 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; sodium hydroxide; dmap; benzotriazol-1-ol; In 1,4-dioxane; dichloromethane; water; acetonitrile; butanone;