475085-56-4Relevant articles and documents
CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF
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, (2016/02/21)
Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
The discovery of BMS-457, a potent and selective CCR1 antagonist
Gardner, Daniel S.,Santella III, Joseph B.,Duncia, John V.,Carter, Percy H.,Dhar, T.G.Murali,Wu, Hong,Guo, Weiwei,Cavallaro, Cullen,Van Kirk, Katy,Yarde, Melissa,Briceno, Stephanie W.,Robert Grafstrom,Liu, Richard,Patel, Sima R.,Tebben, Andrew J.,Camac, Dan,Khan, Javed,Watson, Andrew,Yang, Guchen,Rose, Anne,Foster, William R.,Cvijic, Mary Ellen,Davies, Paul,Hynes Jr., John
, p. 3833 - 3840 (2013/07/25)
A series of compounds which exhibited good human CCR1 binding and functional potency was modified resulting in the discovery of a novel series of high affinity, functionally potent antagonists of the CCR1 receptor. Issues of PXR activity, ion-channel pote
PRODRUGS OF A PIPERIDINYL DERIVATIVE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
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Page/Page column 22, (2011/04/24)
The present application describes prodrugs of the compound of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well a
NOVEL COMPOUNDS USEFUL AS CC CHEMOKINE RECEPTOR LIGANDS
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Page/Page column 32, (2010/07/08)
The present invention relates to novel morpholine, oxazapane and piperidine derivatives that act as ligands for CC chemokine receptors, such as CCR1. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
PIPERIDINYL DERIVATIVE AS A MODULATOR OF CHEMOKINE RECEPTOR ACTIVITY
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Page/Page column 14, (2010/01/30)
The present application describes the compound of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune
Chemokine receptor antagonists and methods of use thereof
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, (2008/06/13)
Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof.
CCR1 antagonists and methods of use therefor
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Page/Page column 8, (2010/02/07)
The invention provides compounds having the formula: wherein R1 is halogen. The invention also provides compositions comprising the compounds, and methods of treating diseases or disorders that comprise administering one or more of the compound
Chemokine receptor anagonists and methods of use therefor
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, (2008/06/13)
Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.