homovanillic acid pentafluorophenyl ester

Base Information

• Chemical Name: homovanillic acid pentafluorophenyl ester
• CAS No.: 289903-64-6
• Molecular Formula: C₁₅H₉F₅O₄
• Molecular Weight: 348.226
• Mol file: 289903-64-6.mol

Synonyms:homovanillic acid pentafluorophenyl ester

Chemical Property of homovanillic acid pentafluorophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of homovanillic acid pentafluorophenyl ester

There total 2 articles about homovanillic acid pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3,4,5,6-pentafluorophenol (771-61-9) + Homovanillic acid (306-08-1) + 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride (25952-53-8) → homovanillic acid pentafluorophenyl ester (289903-64-6)

Guidance literature:

In dichloromethane; at 20 ℃; for 18h;

Reference yield:

2,3,4,5,6-pentafluorophenol (771-61-9) + Homovanillic acid (306-08-1) → homovanillic acid pentafluorophenyl ester (289903-64-6)

Guidance literature:

With dicyclohexyl-carbodiimide;

DOI:10.1016/S0968-0896(01)00387-X

Reference yield: 79.0%

2,2-dimethyl-propionic acid 2-amino-3-(4-tert-butyl-phenyl)-propyl ester; compound with trifluoro-acetic acid + homovanillic acid pentafluorophenyl ester (289903-64-6) → 2,2-dimethyl-propionic acid 3-(4-tert-butyl-phenyl)-2-[2-(4-hydroxy-3-methoxy-phenyl)-acetylamino]-propyl ester

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmc.2003.12.005

upstream raw materials:

2,3,4,5,6-pentafluorophenol

Homovanillic acid

1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride

Downstream raw materials:

LJO-198

N-[3-pivaloyloxy-2-(4-t-butylbenzyl)propyl]-2-(4-hydroxy-3-methoxyphenyl)acetamide

Refernces

• 1、 Lee, Jeewoo,Lee, Jiyoun,Kang, Myung-Sim,Kim, Kang-Pil,Chung, Suk-Jae,Blumberg, Peter M.,Yi, Jung-Bum,Park, Young Ho. "Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics". . p. 1171 - 1179. Retrieved 2007/10/03.