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EDCI (1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Hydrochloride)

Base Information Edit
  • Chemical Name:EDCI (1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Hydrochloride)
  • CAS No.:25952-53-8
  • Molecular Formula:C8H18ClN3
  • Molecular Weight:191.704
  • Hs Code.:29252000
  • Mol file:25952-53-8.mol
EDCI (1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Hydrochloride)

Synonyms:SCHEMBL1765287

Suppliers and Price of EDCI (1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Hydrochloride)
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • N-Ethyl-N’-(3-dimethylaminopropyl)carbodimideHydrochloride
  • 1g
  • $ 65.00
  • TRC
  • N-Ethyl-N’-(3-dimethylaminopropyl)carbodimideHydrochloride
  • 10g
  • $ 120.00
  • TCI Chemical
  • 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride [Coupling Agent for Peptides Synthesis] >98.0%(T)
  • 100g
  • $ 416.00
  • TCI Chemical
  • 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride [Coupling Agent for Peptides Synthesis] >98.0%(T)
  • 250g
  • $ 871.00
  • TCI Chemical
  • 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride [Coupling Agent for Peptides Synthesis] >98.0%(T)
  • 25g
  • $ 163.00
  • TCI Chemical
  • 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride [Coupling Agent for Peptides Synthesis] >98.0%(T)
  • 5g
  • $ 51.00
  • SynQuest Laboratories
  • EDChydrochloride 99%
  • 100 g
  • $ 40.00
  • SynQuest Laboratories
  • EDChydrochloride 99%
  • 25 g
  • $ 15.00
  • SynQuest Laboratories
  • EDChydrochloride 99%
  • 500 g
  • $ 150.00
  • SynQuest Laboratories
  • EDChydrochloride 99%
  • 1 kg
  • $ 250.00
Total 288 raw suppliers
Chemical Property of EDCI (1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Hydrochloride) Edit
Chemical Property:
  • Appearance/Colour:White crystalline powder 
  • Vapor Pressure:0.171mmHg at 25°C 
  • Melting Point:110-115 °C(lit.) 
  • Refractive Index:n20/D 1.461  
  • Boiling Point:197.7 °C at 760 mmHg 
  • Flash Point:73.4 °C 
  • PSA:27.96000 
  • Density:0.877g/mLat 20°C(lit.) 
  • LogP:1.93390 
  • Storage Temp.:−20°C 
  • Sensitive.:Hygroscopic 
  • Solubility.:H2O: soluble1 gm/10 ml, clear to very slightly hazy, colorless t 
  • Water Solubility.:Soluble 
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:3
  • Rotatable Bond Count:5
  • Exact Mass:191.1189253
  • Heavy Atom Count:12
  • Complexity:139
Purity/Quality:

99.0% *data from raw suppliers

N-Ethyl-N’-(3-dimethylaminopropyl)carbodimideHydrochloride *data from reagent suppliers

Safty Information:
  • Pictogram(s): CorrosiveC, IrritantXi 
  • Hazard Codes:C,Xi 
  • Statements: 34-36/37/38-41-37/38-20/21/22 
  • Safety Statements: 26-36/37/39-45-37/39-36 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Canonical SMILES:CCN=C=[NH+]CCCN(C)C.[Cl-]
  • General Description 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC or EDCI·HCl) is a water-soluble carbodiimide commonly used as a coupling agent in peptide synthesis and other chemical reactions, particularly for activating carboxylic acids to form amide or ester bonds. It is frequently employed alongside additives like HOBt or NHS to enhance efficiency and minimize side reactions. EDC has been utilized in diverse applications, including the synthesis of opioid receptor ligands, α-keto esters/amides, and peptide moieties, as well as in surface immobilization strategies for biosensors or biocompatible coatings. Its mild reaction conditions and versatility make it a widely adopted reagent in organic and bioconjugate chemistry. **Returned paragraph:** 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC or EDCI·HCl) is a versatile coupling agent widely used in organic and bioconjugate chemistry for activating carboxylic acids to form amide or ester bonds. It is particularly valuable in peptide synthesis, biosensor development, and the preparation of bioactive compounds due to its water solubility and compatibility with mild reaction conditions. EDC is often paired with additives like HOBt or NHS to improve reaction efficiency and selectivity. Its applications span pharmaceutical synthesis, surface modification, and the creation of functional biomaterials. *(Note: The conclusion integrates relevant uses from the provided abstracts while omitting literature-specific descriptions.)*
Technology Process of EDCI (1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Hydrochloride)

There total 8 articles about EDCI (1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Hydrochloride) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With triethylamine hydrochloride; In acetonitrile; at 15 ℃; for 1h; Temperature;
Refernces Edit

Biosensor-Based Determination of Riboflavin in Milk Samples

10.1021/ac034876a

The study presents the development of a biosensor-based assay for the quantification of riboflavin (Rf) in milk samples using surface plasmon resonance (SPR) technology. The assay involves the indirect measurement of Rf by detecting the excess of riboflavin binding protein (RBP) that remains free after complexation with Rf molecules originally present in the sample. The sensor chip is modified with covalently immobilized Rf to bind the excess RBP. The method involves a chemical modification to introduce a reactive ester group on the Rf molecule for immobilization on the chip surface. Calibration solutions are prepared by mixing Rf standard solutions with an optimized concentration of RBP, and the Rf content in milk samples is measured by comparing the response against the calibration. The results are comparable to those obtained from an official HPLC-fluorescence procedure, with a limit of quantification determined to be 234 μg/L and a limit of detection to 70 μg/L. The study demonstrates the potential of SPR-based biosensors as a competitive alternative to traditional analytical techniques for the determination of riboflavin in food samples.

Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3′-carboxamido)morphinan analogues as opioid receptor ligands

10.1016/j.bmc.2015.02.055

The research focuses on the design, synthesis, and pharmacological evaluation of a series of 17-cyclopropylmethyl-3,14b-dihydroxy-4,5a-epoxy-6a-(isoquinoline-3-carboxamido)morphinan (NAQ) analogues. These compounds were developed to study their structure-activity relationship at the mu opioid receptor (MOR). The experiments involved competition binding assays, functional assays like the [35S]GTPcS binding assay, and in vivo tests such as the warm-water tail immersion assay for antinociception and opioid withdrawal assays in mice. The reactants used in the synthesis of these analogues included substituted isoquinoline-3-carboxylic acids and naltrexone derivatives, with coupling reactions facilitated by EDCI/HOBt. The analyses included radioligand binding assays for receptor affinity and selectivity, functional assays for agonism/antagonism at MOR, and in vivo assays for antinociceptive effects and opioid withdrawal symptoms. The study also utilized molecular dynamics simulation to understand the binding affinities and selectivity of the compounds at different opioid receptors.

Synthesis of α-keto esters and amides via oxidative cleavage of cyanoketophosphoranes by dimethyldioxirane

10.1021/jo0015974

The research focuses on the synthesis of R-keto esters and amides, which are crucial functional groups for inhibitors of hydrolytic enzymes such as serine and cysteine proteases. The study extends the method of oxidative cleavage of cyanoketophosphoranes using dimethyldioxirane as a mild and selective oxidant, followed by trapping with nucleophiles to yield the desired R-keto compounds. The experiments involved the preparation of cyanoketophosphoranes by coupling corresponding carboxylic acids with (cyanomethylene)phosphorane in the presence of EDCI. The oxidative cleavage was performed by adding dimethyldioxirane to solutions of cyanoketophosphoranes in MeOH for esters or in CH2Cl2 at -78 °C for amides, followed by the addition of the appropriate amine or alcohol nucleophile. The analyses used to characterize the products included flash column chromatography, analytical TLC, NMR spectroscopy (1H and 13C), infrared spectroscopy (IR), electron impact mass spectrometry (EIMS), and high-resolution mass spectrometry (HRMS). The study successfully demonstrated a mild and efficient method for synthesizing R-keto esters and amides with short reaction times and simple workup procedures.

π-deficient 2-(arylsulfonyl)ethyl esters as protecting groups for carboxylic acids

10.1055/s-2003-36844

The research investigates π-deficient 2-(arylsulfonyl)ethyl esters as protecting groups for carboxylic acids. The study explores the synthesis, protection, and deprotection processes of various π-deficient 2-(arylsulfonyl)ethyl groups. Key chemicals involved include thiophenols, 2-bromoethanol, H2O2, NaHCO3, MnSO4·H2O, EDC (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride), DMAP (4-dimethylaminopyridine), and various carboxylic acids such as hydrocinnamic acid and trans-cinnamic acid. The researchers optimized the reaction conditions for both the protection and deprotection steps, finding that the 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl group is particularly effective and easily removed under mild basic conditions using aqueous NaHCO3. The study highlights the efficiency, high yields, and mild reaction conditions of this new protecting group, making it a promising alternative to existing carboxylic acid protecting agents.

Synthesis of the peptide moiety of the jamaicamides

10.1016/j.tetlet.2011.07.078

The research focuses on the stereoselective synthesis of the peptide moiety of jamaicamides, which are marine natural products with sodium channel blocking properties. The synthesis begins with natural amino acids, L-alanine and N-Boc-β-alanine, and utilizes Meldrum's acid as a key reactant. The researchers detail the preparation of two segments of the peptide: the pyrrolidone ring and the N-Boc-β-methoxy enone carboxylic acid. Various reagents such as EDC·HCl, DMAP, NaBH4, and LiHMDS are used in a series of reactions including condensation, reduction, and amide bond formation. Analytical techniques likely employed, though not explicitly mentioned in the paragraph, include NMR spectroscopy and mass spectrometry for compound characterization. The study also discusses alternative routes and yields for different steps, aiming to optimize the synthesis process.

Facile and universal immobilization of l-lysine inspired by mussels

10.1039/c2jm16598h

The study presents the synthesis and application of a novel molecule, lysine-dopamine (LDA), which was inspired by the adhesive properties of mussels and the bio-functionality of L-lysine. LDA serves as a universal modifier for various surfaces to enhance their biocompatibility, cell adhesion, and promote cell growth. The chemicals used in the study include L-lysine, N-hydroxysuccinimide (NHS), di-t-butyl dicarbonate ((Boc)2O), dopamine hydrochloride (DA-HCl), and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC-HCl) for the synthesis of LDA. These chemicals were utilized in a series of reactions to create LDA, which was then applied to different substrates through a simple dip-coating process. The purpose of these chemicals was to create a functional molecule that could mimic the strong adhesion properties of mussel proteins and improve the biocompatibility of surfaces for biomedical applications.

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