2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-pyrazol-3-yl)-1-(5-(4-(trifluoromethoxy)phenyl)-pyridin-2-yl)propan-2-ol

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Chemical Name:2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-pyrazol-3-yl)-1-(5-(4-(trifluoromethoxy)phenyl)-pyridin-2-yl)propan-2-ol
CAS No.:1340593-86-3
Molecular Formula:C₂₄H₁₆F₇N₃O₂
Molecular Weight:511.399
Hs Code.:

Synonyms:2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-pyrazol-3-yl)-1-(5-(4-(trifluoromethoxy)phenyl)-pyridin-2-yl)propan-2-ol

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Chemical Property of 2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-pyrazol-3-yl)-1-(5-(4-(trifluoromethoxy)phenyl)-pyridin-2-yl)propan-2-ol

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Technology Process of 2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-pyrazol-3-yl)-1-(5-(4-(trifluoromethoxy)phenyl)-pyridin-2-yl)propan-2-ol

There total 4 articles about 2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-pyrazol-3-yl)-1-(5-(4-(trifluoromethoxy)phenyl)-pyridin-2-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: C₂₃H₁₄F₇NO₂

: 18107-18-1
diazomethyl-trimethyl-silane

: 1340593-86-3
2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-pyrazol-3-yl)-1-(5-(4-(trifluoromethoxy)phenyl)-pyridin-2-yl)propan-2-ol

Guidance literature:: at 120 ℃; for 15h;

Reference yield:

: 294181-95-6
2-(5-bromopyridine-2-yl)-2,2-difluoroacetic acid ethyl ester

: 1340593-86-3
2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-pyrazol-3-yl)-1-(5-(4-(trifluoromethoxy)phenyl)-pyridin-2-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / diethyl ether / 3 h / -70 - 20 °C

2.1: sodium hydrogencarbonate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / water; tetrahydrofuran / 2.5 h / 20 - 65 °C / Inert atmosphere

3.1: mercury dichloride; magnesium / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

3.2: 2 h / -20 °C

4.1: 15 h / 120 °C

With n-butyllithium; sodium hydrogencarbonate; magnesium; mercury dichloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In tetrahydrofuran; diethyl ether; water;

Reference yield:

: 294182-06-2
2-(5-bromopyridin-2-yl)-1-(2,4-difluorophenyl)-2,2-difluoroethanone

: 1340593-86-3
2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-pyrazol-3-yl)-1-(5-(4-(trifluoromethoxy)phenyl)-pyridin-2-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / water; tetrahydrofuran / 2.5 h / 20 - 65 °C / Inert atmosphere

2.1: mercury dichloride; magnesium / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

2.2: 2 h / -20 °C

3.1: 15 h / 120 °C

With sodium hydrogencarbonate; magnesium; mercury dichloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In tetrahydrofuran; water;