benzyl <<<4-<(tert-butoxycarbonyl)methoxy>piperidinyl>carbonyl>methyl>carbamate

Base Information

Chemical Name:benzyl <<<4-<(tert-butoxycarbonyl)methoxy>piperidinyl>carbonyl>methyl>carbamate
CAS No.:144412-44-2
Molecular Formula:C₂₁H₃₀N₂O₆
Molecular Weight:406.479
Hs Code.:

Synonyms:benzyl <<<4-<(tert-butoxycarbonyl)methoxy>piperidinyl>carbonyl>methyl>carbamate

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Chemical Property of benzyl <<<4-<(tert-butoxycarbonyl)methoxy>piperidinyl>carbonyl>methyl>carbamate

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Technology Process of benzyl <<<4-<(tert-butoxycarbonyl)methoxy>piperidinyl>carbonyl>methyl>carbamate

There total 5 articles about benzyl <<<4-<(tert-butoxycarbonyl)methoxy>piperidinyl>carbonyl>methyl>carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 144412-03-3
(Piperidin-4-yloxy)-acetic acid tert-butyl ester

: 56-40-6,18875-39-3,25718-94-9
glycine

: 144412-44-2
benzyl <<<4-<(tert-butoxycarbonyl)methoxy>piperidinyl>carbonyl>methyl>carbamate

Guidance literature:: With 4-methyl-morpholine; In dichloromethane;

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 144412-44-2
benzyl <<<4-<(tert-butoxycarbonyl)methoxy>piperidinyl>carbonyl>methyl>carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / triethylamine (TEA) / CH₂Cl₂ / 16 h / Ambient temperature

2: 76 percent / tetra-n-butylammonium hydrogen sulfate, aq. NaOH / CH₂Cl₂; H₂O / 16 h

3: 94 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 760 Torr

4: 1.)2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT), N-methylmorpholine (NMM), 2.) N-methylmorpholine (NMM) / 1.) CH₂Cl₂, 0 deg C, 3 h, 2.) CH₂Cl₂, RT, 12 h

With 4-methyl-morpholine; sodium hydroxide; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; water;
DOI:10.1021/jm00101a017

Reference yield:

: 95798-23-5
1-(benzyloxycarbonyl)-4-hydroxypiperidine

: 144412-44-2
benzyl <<<4-<(tert-butoxycarbonyl)methoxy>piperidinyl>carbonyl>methyl>carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / tetra-n-butylammonium hydrogen sulfate, aq. NaOH / CH₂Cl₂; H₂O / 16 h

2: 94 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 760 Torr

3: 1.)2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT), N-methylmorpholine (NMM), 2.) N-methylmorpholine (NMM) / 1.) CH₂Cl₂, 0 deg C, 3 h, 2.) CH₂Cl₂, RT, 12 h

With 4-methyl-morpholine; sodium hydroxide; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; palladium on activated charcoal; In ethanol; dichloromethane; water;
DOI:10.1021/jm00101a017