C₁₈H₂₀N₄O₂

Base Information

• Chemical Name: C₁₈H₂₀N₄O₂
• CAS No.: 944576-49-2
• Molecular Formula: C₁₈H₂₀N₄O₂
• Molecular Weight: 324.382
• Mol file: 944576-49-2.mol

Synonyms:C₁₈H₂₀N₄O₂

Chemical Property of C₁₈H₂₀N₄O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₂₀N₄O₂

There total 4 articles about C₁₈H₂₀N₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-nitro-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine (129018-59-3) → C18H20N4O2 (944576-49-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / hydrazine hydrate / Pd/C / tetrahydrofuran / 1.5 h / -20 - 0 °C

2: 99 percent Chromat_. / D₂O; dimethylformamide-d7 / 0.33 h / 0 °C

With hydrazine hydrate; palladium on activated charcoal; In tetrahydrofuran; d₇-N,N-dimethylformamide; water-d2;

DOI:10.1021/jo070306p

Reference yield:

2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine (105650-23-5) → C18H20N4O2 (944576-49-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 52 percent Turnov_. / NaNO₂; acetic acid / H₂O / 3.5 h / 0 - 20 °C

2: 93 percent / hydrazine hydrate / Pd/C / tetrahydrofuran / 1.5 h / -20 - 0 °C

3: 99 percent Chromat_. / D₂O; dimethylformamide-d7 / 0.33 h / 0 °C

With hydrazine hydrate; acetic acid; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; d₇-N,N-dimethylformamide; water; water-d2;

DOI:10.1021/jo070306p

Reference yield:

1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine (125572-33-0) → C18H20N4O2 (944576-49-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 20 percent Turnov_. / 15-crown-5; NaNH₂ / xylene / 1.5 h / 130 °C

2: 52 percent Turnov_. / NaNO₂; acetic acid / H₂O / 3.5 h / 0 - 20 °C

3: 93 percent / hydrazine hydrate / Pd/C / tetrahydrofuran / 1.5 h / -20 - 0 °C

4: 99 percent Chromat_. / D₂O; dimethylformamide-d7 / 0.33 h / 0 °C

With 15-crown-5; hydrazine hydrate; sodium amide; acetic acid; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; d₇-N,N-dimethylformamide; water; water-d2; xylene; 1: Chichibabin reaction;

DOI:10.1021/jo070306p

upstream raw materials:

pivaloyl cyanide

N-Hydroxy-PhIP

2-nitro-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine

2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine

Downstream raw materials:

1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine