methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-7-(2-methyl-1-propen-1-yl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Base Information

Chemical Name:methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-7-(2-methyl-1-propen-1-yl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate
CAS No.:1336967-04-4
Molecular Formula:C₃₃H₃₈F₃N₃O₂
Molecular Weight:565.679
Hs Code.:

Synonyms:methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-7-(2-methyl-1-propen-1-yl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

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Chemical Property of methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-7-(2-methyl-1-propen-1-yl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

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Technology Process of methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-7-(2-methyl-1-propen-1-yl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

There total 6 articles about methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-7-(2-methyl-1-propen-1-yl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 14559-88-7
2,2-dimethylethenylboronic acid

: 1336967-02-2
methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-7-bromo-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

: 1336967-04-4
methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-7-(2-methyl-1-propen-1-yl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 150 ℃; for 0.333333h; Sealed tube;

Reference yield:

: 591-19-5
m-Bromoaniline

: 1336967-04-4
methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-7-(2-methyl-1-propen-1-yl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate / water / 2 h / 35 - 90 °C

2.1: sulfuric acid / 0.75 h / 65 - 80 °C

2.2: 60 °C

3.1: potassium hydroxide / ethanol; water / 0.25 h

3.2: 18 h / Reflux

3.3: pH 4 - 5

4.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C

5.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 18 h / 100 °C

5.2: 2 h / 20 °C

6.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 150 °C / Sealed tube

With hydrogenchloride; N-Bromosuccinimide; sulfuric acid; hydroxylamine hydrochloride; potassium carbonate; sodium sulfate; potassium hydroxide; dibenzoyl peroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; 6.1: Suzuki Coupling;

Reference yield:

: 6326-79-0
6-bromoisatin

: 1336967-04-4
methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-7-(2-methyl-1-propen-1-yl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol; water / 0.25 h

1.2: 18 h / Reflux

1.3: pH 4 - 5

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 18 h / 100 °C

3.2: 2 h / 20 °C

4.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 150 °C / Sealed tube

With N-Bromosuccinimide; potassium carbonate; potassium hydroxide; dibenzoyl peroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; 4.1: Suzuki Coupling;