2-{8-methyl-11-oxo-5H-dibenzo[b,e][1,4]diazepin-10-(11H)-yl}benzonitrile

Base Information

Chemical Name:2-{8-methyl-11-oxo-5H-dibenzo[b,e][1,4]diazepin-10-(11H)-yl}benzonitrile
CAS No.:1628347-66-9
Molecular Formula:C₂₁H₁₅N₃O
Molecular Weight:325.37
Hs Code.:

Synonyms:2-{8-methyl-11-oxo-5H-dibenzo[b,e][1,4]diazepin-10-(11H)-yl}benzonitrile

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Chemical Property of 2-{8-methyl-11-oxo-5H-dibenzo[b,e][1,4]diazepin-10-(11H)-yl}benzonitrile

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Technology Process of 2-{8-methyl-11-oxo-5H-dibenzo[b,e][1,4]diazepin-10-(11H)-yl}benzonitrile

There total 3 articles about 2-{8-methyl-11-oxo-5H-dibenzo[b,e][1,4]diazepin-10-(11H)-yl}benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 412957-82-5
N-(2-cyanophenyl)-2-iodobenzamide

: 29289-13-2
2-iodo-4-methylaniline

: 1628347-66-9
2-{8-methyl-11-oxo-5H-dibenzo[b,e][1,4]diazepin-10-(11H)-yl}benzonitrile

Guidance literature:: With copper(l) iodide; potassium carbonate; In dimethyl sulfoxide; at 135 ℃; for 14h; Inert atmosphere;
DOI:10.1002/adsc.201301020

Reference yield:

: 88-67-5
2-Iodobenzoic acid

: 1628347-66-9
2-{8-methyl-11-oxo-5H-dibenzo[b,e][1,4]diazepin-10-(11H)-yl}benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 80 °C

2: pyridine / dichloromethane / 0 - 20 °C

3: potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 14 h / 135 °C / Inert atmosphere

With pyridine; copper(l) iodide; thionyl chloride; potassium carbonate; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/adsc.201301020

Reference yield:

: 609-67-6
2-Iodobenzoyl chloride

: 1628347-66-9
2-{8-methyl-11-oxo-5H-dibenzo[b,e][1,4]diazepin-10-(11H)-yl}benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 0 - 20 °C

2: potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 14 h / 135 °C / Inert atmosphere

With pyridine; copper(l) iodide; potassium carbonate; In dichloromethane; dimethyl sulfoxide;
DOI:10.1002/adsc.201301020