1-benzyl-6-benzyloxy-5-(4-benzyloxy-3-methoxy-benzyl)-4-hydroxy-1H-benzo[cd]indol-3-one

Base Information

Chemical Name:1-benzyl-6-benzyloxy-5-(4-benzyloxy-3-methoxy-benzyl)-4-hydroxy-1H-benzo[cd]indol-3-one
CAS No.:1374004-86-0
Molecular Formula:C₄₀H₃₃NO₅
Molecular Weight:607.706
Hs Code.:

Synonyms:1-benzyl-6-benzyloxy-5-(4-benzyloxy-3-methoxy-benzyl)-4-hydroxy-1H-benzo[cd]indol-3-one

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Chemical Property of 1-benzyl-6-benzyloxy-5-(4-benzyloxy-3-methoxy-benzyl)-4-hydroxy-1H-benzo[cd]indol-3-one

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Technology Process of 1-benzyl-6-benzyloxy-5-(4-benzyloxy-3-methoxy-benzyl)-4-hydroxy-1H-benzo[cd]indol-3-one

There total 12 articles about 1-benzyl-6-benzyloxy-5-(4-benzyloxy-3-methoxy-benzyl)-4-hydroxy-1H-benzo[cd]indol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1374004-84-8
1-[5-benzyloxy-3-(2-hydroxy-acetyl)-1-benzyl-1H-indol-4-yl]-2-(4-benzyloxy-3-methoxy-phenyl)-ethanone

: 1374004-86-0
1-benzyl-6-benzyloxy-5-(4-benzyloxy-3-methoxy-benzyl)-4-hydroxy-1H-benzo[cd]indol-3-one

Guidance literature:: 1-[5-benzyloxy-3-(2-hydroxy-acetyl)-1-benzyl-1H-indol-4-yl]-2-(4-benzyloxy-3-methoxy-phenyl)-ethanone; With potassium tert-butylate; In tetrahydrofuran; for 2h; Reflux; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; water; Saturated solution;
DOI:10.1016/j.tet.2012.03.026

Reference yield:

: 1374004-99-5
1-[5-benzyloxy-3-(2-hydroxy-acetyl)-1H-indol-4-yl]-2-(4-benzyloxy-3-methoxy-phenyl)-ethanone

: 1374004-86-0
1-benzyl-6-benzyloxy-5-(4-benzyloxy-3-methoxy-benzyl)-4-hydroxy-1H-benzo[cd]indol-3-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

3.1: dihydrogen peroxide; potassium carbonate / tetrahydrofuran; water / 2 h / 20 °C

4.1: potassium tert-butylate / tetrahydrofuran / 2 h / Reflux; Inert atmosphere

4.2: Saturated solution

With pyridine; potassium tert-butylate; dihydrogen peroxide; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tet.2012.03.026

Reference yield:

: C₃₃H₂₆ClNO₆

: 1374004-86-0
1-benzyl-6-benzyloxy-5-(4-benzyloxy-3-methoxy-benzyl)-4-hydroxy-1H-benzo[cd]indol-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: tri-n-butyl-tin hydride / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

4.1: dihydrogen peroxide; potassium carbonate / tetrahydrofuran; water / 2 h / 20 °C

5.1: potassium tert-butylate / tetrahydrofuran / 2 h / Reflux; Inert atmosphere

5.2: Saturated solution

With pyridine; potassium tert-butylate; dihydrogen peroxide; tri-n-butyl-tin hydride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tet.2012.03.026